生物来源
mouse
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
AW65, monoclonal
种属反应性
mouse, human
制造商/商品名称
Upstate®
技术
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
phosphorylation (pThr69/pThr71)
基因信息
human ... ATF2(1386)
一般描述
Mr 65kDa
免疫原
KLH-conjugated, synthetic peptide containing the sequence ...DQ[pT]P[pT]P... in which [pT] corresponds to phospho-threonine at residues 69 and 71 of human ATF2
应用
Anti-phospho-ATF2 (Thr69/71) Antibody, clone AW65 is a high quality Mouse Monoclonal Antibody for the detection of phospho-ATF2 (Thr69/71) & has been validated in IP & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
生化/生理作用
ATF2 phosphorylated at both Thr69 and Thr71
Predicted to cross-react with rat based on sequence homology
外形
Protein G Purified
Format: Purified
制备说明
stable 2 years at -20°C from date of shipment
分析说明
routinely evaluated by immunoblot with RIPA lysates from anisomycin treated 3T3/NIH cells
其他说明
Replaces: 04-199
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
Shuhui Zheng et al.
Cardiovascular pharmacology: open access, 4(1) (2015-04-01)
The cell type that normally limits the inflammatory and atherosclerotic process is the vascular endothelial cell (EC) that can be regulated by proinflammatory and various stresses. Toll-like receptor-4 (TLR4) plays an important role in the pathogenesis of atherosclerosis, in part
Mumtaz Y Balkhi et al.
iScience, 2, 105-122 (2018-11-15)
T cells infiltrate affected organs in chronic infections and malignancy, but they may fail to eradicate virus-infected cells or tumor because of exhaustion. This report describes a Yin Yang-1 (YY1)-centered mechanism for diverse components that have been correlated with exhaustion.
Ahmad Salameh et al.
The Journal of biological chemistry, 285(30), 23096-23104 (2010-05-29)
Growth factor stimulation induces c-Jun-dependent survival of primary endothelial cells. However, the mechanism of c-Jun anti-apoptotic activity has not been identified. We here demonstrate that in response to growth factor treatment, primary human endothelial cells as well as mouse fibroblasts
Mireille Delhase et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(4), E177-E186 (2011-12-29)
The decision between survival and death in cells exposed to TNF relies on a highly regulated equilibrium between proapoptotic and antiapoptotic factors. The TNF-activated antiapoptotic response depends on several transcription factors, including NF-κB and its RelA/p65 subunit, that are activated
Klára Kirsch et al.
Nature communications, 11(1), 5769-5769 (2020-11-15)
Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively control transcription is not well-understood. Activating protein 1 transcription factors are phosphorylated by mitogen-activated protein kinases (MAPK) in their transactivation domains (TAD) at so-called phosphoswitches
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