06-1125
抗-Ipaf (NLRC4) 抗体
from rabbit, purified by affinity chromatography
别名:
NLR family, CARD domain containing 4, NOD-like receptor C4, caspase recruitment domain family, member 12, ICE-protease activating factor, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4, NLR family CARD domain-
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
western blot
western blot
Species reactivity:
human, mouse
Citations:
17
Technique(s):
immunocytochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-Ipaf (NLRC4) 抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GNL3(26354)
General description
Ipaf，也称为NLRC4，是人CED-4同源物，被认为是半胱天冬酶-1的激活剂，也可能与半胱天冬酶-1的激活有关，作为对促炎和凋亡刺激的反应。它已被证明是由p53诱导的，并有助于p53依赖性细胞凋亡。Ipaf被认为在先天免疫系统的激活中起作用。
观测值〜112 kDa。
Analysis Note
对照
人肺组织裂解液
人肺组织裂解液
已通过蛋白质印迹法在人肺组织裂解液中进行了评估。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人肺组织裂解液中检测到Ipaf。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg人肺组织裂解液中检测到Ipaf。
Application
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
蛋白质印迹分析：1 ug/mL的该抗体在10 ug人肺组织裂解液中检测到Ipaf。
免疫细胞化学分析：一个先前批次以1：500的稀释度在NIH/3T3细胞中检测到Ipaf。
免疫细胞化学分析：一个先前批次以1：500的稀释度在NIH/3T3细胞中检测到Ipaf。
该抗Ipaf (NLRC4)抗体经过验证可用于在IC, WB中检测 Ipaf (NLRC4)。
Biochem/physiol Actions
该抗体可识别Ipaf的LRR4域。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
与人Ipaf (NLRC4)的LRR4域对应的KLH缀合线性肽。
表位：LRR4域
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Rossana G Iannitti et al.
Nature communications, 7, 10791-10791 (2016-03-15)
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses in mice and humans
Congfei Xu et al.
Nature communications, 9(1), 4092-4092 (2018-10-07)
The NLRP3 inflammasome is a well-studied target for the treatment of multiple inflammatory diseases, but how to promote the current therapeutics remains a large challenge. CRISPR/Cas9, as a gene editing tool, allows for direct ablation of NLRP3 at the genomic
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
Canna, SW; de Jesus, AA; Gouni, S; Brooks, SR; Marrero, B; Liu, Y; DiMattia, MA; Zaal et al.
Nature Genetics null
Ho Yin Pekkle Lam et al.
Parasitology international, 77, 102119-102119 (2020-04-14)
Angiostrongylus cantonensis is a metastrongyloid nematode that causes eosinophilic meningoencephalitis in humans. A high infestation of A. cantonensis can cause permanent brain damage or even death. The inflammasome is an oligomeric molecular platform that can detect microbial pathogens and activate
Changhoon Oh et al.
Cell reports, 41(8), 111688-111688 (2022-11-24)
In neutrophils, caspase-11 cleaves gasdermin D (GSDMD), causing pyroptosis to clear cytosol-invasive bacteria. In contrast, caspase-1 also cleaves GSDMD but seems to not cause pyroptosis. Here, we show that this pyroptosis-resistant caspase-1 activation is specifically programmed by the site of
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