一般描述
55kDa
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
免疫原
Trp E fusion-protein corresponding to the N-terminal fragment containing amino acid residues 75-155 of human v-Fos
应用
Detect Fos with Anti-Fos Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
生化/生理作用
c-Fos and v-Fos
外形
Immunoaffinity Chromatography
PBS containing 2mg/ml BSA and 0.2% sodium azide
制备说明
1 year at -20°C
分析说明
Control
Serum-stimulated Hela cell lysate, phorbol ester-treated and EGF-treated A-431 nuclear cell extracts
Serum-stimulated Hela cell lysate, phorbol ester-treated and EGF-treated A-431 nuclear cell extracts
routinely evaluated by immunoblot on RIPA lysate of human HeLa nuclear extract
其他说明
Replaces: CBL441
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10-13 - German Storage Class 10 to 13
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.
Kool, J; Hamdi, M; Cornelissen-Steijger, P; van der Eb, AJ; Terleth, C; van Dam, H
Oncogene null
H He et al.
The Journal of biological chemistry, 273(39), 25015-25019 (1998-09-17)
c-Fos is a transcription factor that promotes cell growth, differentiation, and transformation. We found that c-Fos was degraded when WEHI7.2 mouse lymphoma cells were induced to undergo apoptosis with the calcium ATPase inhibitor, thapsigargin, or the glucocorticoid hormone, dexamethasone. The
c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors.
Yuji Ito, Daisuke Inoue, Shinsuke Kido, Toshio Matsumoto
Bone null
Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor.
Wu, G D, et al.
The Journal of Biological Chemistry, 272, 2396-2403 (1997)
Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes.
Oldak M, Maksym RB, Sperling T, Yaniv M, Smola H, Pfister HJ, Malejczyk J, Smola S
Journal of virology null
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