biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Quality Level
Gene Information
human ... FOS(2353)
General description
55kDa
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
Immunogen
Trp E fusion-protein corresponding to the N-terminal fragment containing amino acid residues 75-155 of human v-Fos
Application
Detect Fos with Anti-Fos Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Biochem/physiol Actions
c-Fos and v-Fos
Physical form
Immunoaffinity Chromatography
PBS containing 2mg/ml BSA and 0.2% sodium azide
Preparation Note
1 year at -20°C
Analysis Note
Control
Serum-stimulated Hela cell lysate, phorbol ester-treated and EGF-treated A-431 nuclear cell extracts
Serum-stimulated Hela cell lysate, phorbol ester-treated and EGF-treated A-431 nuclear cell extracts
routinely evaluated by immunoblot on RIPA lysate of human HeLa nuclear extract
Other Notes
Replaces: CBL441
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10-13 - German Storage Class 10 to 13
H He et al.
The Journal of biological chemistry, 273(39), 25015-25019 (1998-09-17)
c-Fos is a transcription factor that promotes cell growth, differentiation, and transformation. We found that c-Fos was degraded when WEHI7.2 mouse lymphoma cells were induced to undergo apoptosis with the calcium ATPase inhibitor, thapsigargin, or the glucocorticoid hormone, dexamethasone. The
c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors.
Yuji Ito, Daisuke Inoue, Shinsuke Kido, Toshio Matsumoto
Bone null
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.
Kool, J; Hamdi, M; Cornelissen-Steijger, P; van der Eb, AJ; Terleth, C; van Dam, H
Oncogene null
In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo.
Baan, B; Pardali, E; ten Dijke, P; van Dam, H
Molecular and Cellular Proteomics null
Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis.
Jillian de Wilde, Johanna De-Castro Arce, Peter J F Snijders, Chris J L M Meijer et al.
Cellular oncology null
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