97kDa

Metabotropic glutamate receptor 7 (UniProt: Q14831; also known as mGluR7) is encoded by the GRM7 (also known as GPRC1G, MGLUR7) gene (Gene ID: 2917) in human. GRM7 gene is mapped to human chromosome 3p26. L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. GRM7 belongs to Group III, and members of group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. mGluR7 is a multi-pass membrane protein and is synthesized with a signal peptide (aa 1-34), which is subsequently cleaved off to produce the mature protein (aa 35-915). mGluR7 is expressed in several parts of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. It is located in the presynaptic zone of the synaptic cleft of glutamatergic synapses. Five isoforms of mGluR7 have been described that are produced by alternative splicing. The gene coding MGLUR7 is associated with autism and also participates in schizophrenia and bipolar disorder. Dysregulation of mGluR7 has been implicated in several neuropsychiatric disorders, including anxiety, depression, and fragile X syndrome (FXS), where its modulation by allosteric agents like AMN082 has shown therapeutic potential. Studies suggest that drugs targeting mGluR7: mGluR7 agonists, antagonists, and allosteric modulators may play a role as promising agents for the treatment of central nervous system disorders. (Ref.: Li P., et al. (2024). Ageing Res Rev. 102;102554; Palazzo E., et al. (2016). Curr Neuropharmacol. 14(5); 504-513).

对应于人mGluR7氨基酸899-912的肽（C-NSPAAKKKYVSYNN）

抗mGluR7抗体经过验证可用在WB中检测mGluR7。

研究子类别
膜泡运输

神经退行性疾病

研究类别
神经科学

mGluR7

形式：纯化

蛋白A层析

在-20°C下可保存2年

已通过免疫印迹对大鼠脑微粒体制剂进行常规评估

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