07-810
Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody
Upstate®, from rabbit
别名:
c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)
生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human
种属反应性（根据同源性预测）
rat (based on 100% sequence homology)
制造商/商品名称
Upstate®
技术
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pTyr1230/pTyr1234/pTyr1235)
基因信息
human ... MET(4233)
mouse ... Met(17295)
rat ... Met(24553)
一般描述
155 kDa
免疫原
Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-c-Met (Tyr1230/Tyr1234/Tyr1235)
应用
Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody is an antibody against phospho-Met (Tyr1230/Tyr1234/Tyr1235) for use in IC, IF & WB.
Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-Met (Tyr1230/Tyr1234/Tyr1235) in RIPA lysate of HGF treated 293T cells.
生化/生理作用
Recognizes Met phosphorylated on both Tyr1234/Tyr1235 and Tyr1230/Tyr1234/Tyr1235.
分析说明
Routinely evaluated by immunoblot.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
P Longati et al.
Oncogene, 9(1), 49-57 (1994-01-01)
The tyrosine kinase encoded by the MET proto-oncogene (p190MET) is the receptor for Hepatocyte Growth Factor/Scatter Factor (HGF/SF). Previous work has shown that autophosphorylation of p190MET enhances its enzymatic activity and that the major phosphorylation site is Tyr1235, located in
Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity.
Federica Chiara et al.
The Journal of biological chemistry, 278(31), 29352-29358 (2003-05-15)
The met oncogene, encoding the high affinity hepatocyte growth factor receptor, is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus. Intriguingly, mutated Met requires ligand stimulation in order to
Kwang-Hoon Song et al.
Hepatology (Baltimore, Md.), 46(6), 1993-2002 (2007-10-10)
Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced immediately after partial hepatectomy and
Xiaobin Wang et al.
Journal of cellular and molecular medicine, 25(21), 10164-10174 (2021-10-16)
Mantle cell lymphoma (MCL) is a haematologic malignancy. The proteasome inhibitor (PI) bortezomib has been approved to treat MCL, but resistance has emerged through mechanisms that remain unclear. This study aimed to explore the mechanism of PI resistance in MCL
A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
Hov, H?kon, et al
Clinical cancer research : an official journal of the American Association for Cancer Research, 10, 6686-6694 (2004)
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