1.37206
N1-Methyl-pseudouridine 5′-triphosphate
100 mM Sodium Solution, EMPROVE® EXPERT
别名:
1-N-Methyl-pseudo-UTP, N1-Me-pUTP, m1ΨTP
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关于此项目
Assay:
≥99%
Biological source:
synthetic
Form:
solution
Storage temp.:
-10 to -25°C
biological source
synthetic
Quality Level
grade
GMP, Halal, Kosher
product line
EMPROVE® EXPERT
assay
≥99%
form
solution
technique(s)
in vitro transcription (IVT): suitable
pH
7.0 ± 0.1
foreign activity
low in endotoxins
storage temp.
-10 to -25°C
SMILES string
O[C@H]1[C@@H](O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@H]1O)C=2C(=O)NC(=O)N(C)C2
InChI
InChI=1S/C10H17N2O15P3/c1-12-2-4(9(15)11-10(12)16)8-7(14)6(13)5(25-8)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-8,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,8+/m1/s1
InChI key
OLRONOIBERDKRE-XUTVFYLZSA-N
General description
mRNA therapies represent a revolutionary approach to therapeutics such as vaccines, cancer treatments, and immunotherapies, offering novel ways to treat complex diseases. As a result, global interest in mRNA manufacturing has grown, while regulatory expectations have become increasingly exacting. In this environment, manufacturers require raw materials suitable for pharmaceutical use, ensuring the highest levels of quality and purity for successful mRNA production.
In response, we have developed the high-purity NTP Emprove® Expert portfolio, compliant with IPEC-PQG GMP standards, to ensure batch-to-batch consistency in your mRNA manufacturing processes. These critical raw materials are accompanied by comprehensive Emprove® dossiers, providing essential regulatory support to navigate the complexities of the biopharmaceutical industry while ensuring compliance and accelerating time to market. As part of our SAFC® portfolio, these high-quality raw materials are designed to meet the specific needs of pharma and biopharma production.
In response, we have developed the high-purity NTP Emprove® Expert portfolio, compliant with IPEC-PQG GMP standards, to ensure batch-to-batch consistency in your mRNA manufacturing processes. These critical raw materials are accompanied by comprehensive Emprove® dossiers, providing essential regulatory support to navigate the complexities of the biopharmaceutical industry while ensuring compliance and accelerating time to market. As part of our SAFC® portfolio, these high-quality raw materials are designed to meet the specific needs of pharma and biopharma production.
Application
Nucleoside triphosphates (NTPs) are the key building blocks for messenger RNA (mRNA) constructs, which have valuable use as vaccines and therapeutics. The production of mRNA is carried out in an in vitro transcription (IVT) reaction, where enzymes use a plasmid DNA template to catalyze the linking of the NTP building blocks to create mRNA of the desired sequence. Our Emprove® Expert NTPs are designed to align with best practice IVT methods for mRNA manufacturing, possessing all the necessary chemical and biological properties for reliable production of therapeutic mRNA:
- 100 mM sodium salt solution
- Neutral pH (7.0 ± 0.1)
- High chemical purity (≥99%)
- Low endotoxin and bioburden
- DNase and RNase-free
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC Pharma is a registered trademark of Sigma-Aldrich Co. LLC
Disclaimer
Purchaser shall at all times be solely responsible for obtaining all necessary licenses and rights to use this product for its intended application and any compliance with existing laws and regulations. Purchaser understands that the seller is not liable for any patent infringement claims related to Purchaser’s use of this product
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