跳转至内容
Merck
CN

17-218

Ras激活检测试剂盒

别名:

Ras活性检测

登录 查看组织和合同定价。

选择尺寸


关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Quality Level

Gene Information

human ... MRAS(22808)

Analysis Note

该试剂盒从已装有GTPγS的HeLa细胞裂解物中沉淀出Ras-GTP。使用1 μg/ml抗Ras克隆RAS10通过蛋白质免疫印迹检测沉淀的Ras-GTP

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

肌肉RAS癌基因同源物(MRAS)在心血管疾病中起关键作用。该MRAS基因编码GTP结合蛋白的ras超家族的一员。MRAS存在于所有组织中,特别是心血管系统中。它参与信号转导,包括细胞生长和分化。

Other Notes

Ras检测试剂(Raf-1 RBD,琼脂糖)(目录号14-278)

Anti-Ras,克隆RAS10(目录号05-516)

100X GTPγS,10mM(目录号20-176)

100X GDP,100mM(目录号20-177)

Mg2+裂解/洗涤缓冲液,5X(目录号20-168)
替代:SGT435

Packaging

试剂盒容量:30次测定

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionEnvironment

signalword

Danger

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

存储类别

10 - Combustible liquids

法规信息

常规特殊物品
低风险生物材料
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Fu-Ming Tsai et al.
Cellular signalling, 18(3), 349-358 (2005-07-12)
The retinoid-inducible gene 1 (RIG1) protein is a retinoid-inducible growth regulator. Previous studies have shown that the RIG1 protein inhibits the signaling pathways of Ras/mitogen-activated protein kinases. However, neither the mode of action nor the site of inhibition of RIG1
X Shen et al.
The Biochemical journal, 352 Pt 3, 913-919 (2000-12-06)
Interleukin 1beta (IL-1beta) suppresses the IL-6-dependent induction of type II acute-phase response genes, but the underlying mechanism for this suppression remains uncertain. Here we report that treatment of human hepatocullular carcinoma HepG2 cells with IL-1beta inhibited the IL-6-dependent binding of
AnhCo Nguyen et al.
Molecular and cellular biology, 22(9), 3035-3045 (2002-04-10)
While scaffold proteins are thought to be key components of signaling pathways, their exact function is unknown. By preassembling multiple components of signaling cascades, scaffolds are predicted to influence the efficiency and/or specificity of signaling events. Here we analyze a
Richard J Calvert et al.
Analytical biochemistry, 343(2), 283-292 (2005-07-16)
Accurate measurement of activity of wild-type K-ras protein is important due to its tumor suppressor action in tissues such as lung. A published method by Taylor and co-workers uses plasmid-containing Escherichia coli cells to produce a glutathione-S-transferase/raf-1 ras binding domain
Shin-ichiro Miura et al.
Biochemical and biophysical research communications, 306(4), 924-929 (2003-06-25)
Since we recently reported that high density lipoprotein, which contains the bioactive lipid sphingosine-1-phosphate (S1P) [Arterioscler. Thromb. Vasc. Biol. 23 (2003) 802], induced human coronary artery endothelial cell (HCEC) tube formation mediated by a Ras/Raf/ERK (extracellular signal-activated kinase) pathway, we

商品

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

相关内容

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持