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Merck
CN

178260

Anti-α1-Antitrypsin Mouse mAb (TMF1#4B5)

liquid, clone TMF1#4B5, Calbiochem®

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UNSPSC Code:
12352203
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biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

TMF1#4B5, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

isotype

IgG2a

shipped in

wet ice

storage temp.

−20°C

Quality Level

General description

Purified mouse monoclonal antibody. Recognizes α1-antitrypsin in human serum.
Recognizes α1-antitrypsin in human serum. Does not cross-react with α1-acid glycoprotein, serum albumin, or other serum proteins.
  • Antibody Target Gene Symbol: SerpinA3
  • Target Synonym: AACT, ACT, ALPHA 1 ANTICHYMOTRYPSIN, ALPHA1 ACT, Alpha1-antitrypsin proteinase inhibitor, Anti-chymotrypsin, Contrapsin Like Protease Inhibitor Related, Contraspin-like protease inhibitor, CPi-26, Eb22/5, GIG24, GIG25, MGC88254, MGC93363, Serine protease inhibitor, Serpina3n, Spi-2.2, SPI2-2, Spi2/eb.4, SPI3, Spin2c, Spin3
  • Entrez Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
  • Hu Entrez ID: 12
  • Mu Entrez ID: 20716
  • Rat Entrez ID: 24795
  • This Anti-α₁-Antitrypsin Mouse mAb (TMF1#4B5) is validated for use in Enzyme Immunoassay, Radioimmunoassay for the detection of α₁-Antitrypsin.

    Immunogen

    Human
    purified human α₁-antitrypsin

    Application

    Enzyme Immunoassay (see comments)

    Radioimmunoassay (see comments)

    Packaging

    Please refer to vial label for lot-specific concentration.

    Physical form

    In PBS, pH 7.4.

    Preparation Note

    Following initial thaw, aliquot and freeze (-20°C).

    Other Notes

    Does not cross-react with α1-acid glycoprotein, serum albumin, or other serum proteins. Affinity constant: 1 x 109 l/mol. For EIA and RIA, antibody should be titrated for each individual system.

    Legal Information

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

    Disclaimer

    Toxicity: Highly Toxic (H)

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    存储类别

    10-13 - German Storage Class 10 to 13

    法规信息

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    A Lieber et al.
    Journal of virology, 71(11), 8798-8807 (1997-10-29)
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    A Lieber et al.
    Journal of virology, 72(11), 9267-9277 (1998-10-10)
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    Journal of separation science, 35(22), 3124-3129 (2012-10-16)
    An international team including 12 laboratories from 11 independent biopharmaceutical companies in the United States and Switzerland was formed to evaluate the precision and robustness of imaged capillary isoelectric focusing for the charge heterogeneity analysis of monoclonal antibodies. The different
    Guadalupe Ortiz-Muñoz et al.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(9), 3129-3139 (2009-05-07)
    Various studies using proteomic approaches have shown that HDL can carry many proteins other than its constitutive apolipoprotein A-I (apoA-I). Using mass spectrometry and Western blotting, we showed the presence of alpha(1)-antitrypsin (AAT) (SERPINA1, serpin peptidase inhibitor, clade A, an
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    Scientific reports, 11(1), 2291-2291 (2021-01-29)
    Coronavirus disease 2019 (COVID-19) pandemic is affecting millions of patients worldwide. The consequences of initial exposure to SARS-CoV-2 go beyond pulmonary damage, with a particular impact on lipid metabolism. Decreased levels in HDL-C were reported in COVID-19 patients. Since HDL

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