203671
Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem
Acts as a ligand of the adenine nucleotide translocator.
别名:
Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem, 3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
质量水平
方案
≥92% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
beige-pink
溶解性
DMSO: 100 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
生化/生理作用
Cell permeable: no
Primary Target
Mitochondrial mega channel
Mitochondrial mega channel
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
其他说明
Hirsch, T., et al. 1998. J. Immunol. 161, 35.
Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
储存分类代码
10-13 - German Storage Class 10 to 13
Ambre M Bertholet et al.
Nature, 606(7912), 180-187 (2022-05-26)
Mitochondria generate heat due to H+ leak (IH) across their inner membrane1. IH results from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat2-6 and ADP/ATP carrier (AAC) in other tissues1,7-9, but the underlying mechanism
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