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Merck
CN

208293

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01

The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

别名:

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, TMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I

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关于此项目

经验公式（希尔记法）:
C18H21NO4S
化学文摘社编号:
407587-33-1
分子量:
347.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02919058

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产品名称

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01, The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

InChI key

ACLUEOBQFRYTQS-UHFFFAOYSA-N

SMILES string

CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 50 mg/mL, pale yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Disclaimer

Toxicity: Standard Handling (A)

General description

An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).

Other Notes

Fuente, R., et al. 2011, Mol Pharmacol.73, 758.
Namkung, W., et al. 2011, J Biol Chem.286, 2365.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Xiao-Long Li et al.
British journal of pharmacology, 179(12), 3043-3060 (2021-12-29)
Renal fibrosis is the final common outcome in most forms of chronic kidney disease (CKD). However, the underlying causal mechanisms remain obscure. The present study examined whether transmembrane member 16A (TMEM16A), a Ca2+ -activated chloride channel, contributes to the progression
F Christopher Peritore-Galve et al.
Gut microbes, 15(1), 2225841-2225841 (2023-06-23)
Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. However, the pathophysiological causes of diarrhea during CDI are not

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