biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
rat, gerbil, mouse, salamander, chicken, monkey, fish, human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Anti-Cannabinoid Receptor CB₁ (1-77), rabbit polyclonal, recognizes the ~60 kDa CB1 receptor in wide variety of vertebrates. It is validated for use in immunoblotting and with paraffin sections.
Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~60 kDa CB1 receptor protein.
Recognizes the ~60 kDa CB1 receptor protein.
Immunogen
Rat
a recombinant protein consisting of the first 77 amino acids of rat CB₁ receptor
Application
Immunoblotting (1:1000)
Immunocytochemistry (1:100-1:1000)
Paraffin Sections (see comments)
Immunocytochemistry (1:100-1:1000)
Paraffin Sections (see comments)
Physical form
In PBS, 1 mg/ml BSA, 50% glycerol.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Analysis Note
Positive Control
Hippocampal neurons
Hippocampal neurons
Other Notes
May also recognize weaker bands at ~23 kDa, ~72 kDa, and ~180 kDa in some tissues. Immunocytochemical staining of living or fixed cultured hippocampal neurons show intense, punctate staining along processes with little staining over cell bodies. Variables associated with assay conditions will dictate the optimal working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
10-13 - German Storage Class 10 to 13
Francesca Guida et al.
Brain, behavior, and immunity, 85, 128-141 (2019-04-07)
Recent evidence points to the gut microbiota as a regulator of brain and behavior, although it remains to be determined if gut bacteria play a role in chronic pain. The endocannabinoid system is implicated in inflammation and chronic pain processing
Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala.
Angelo Blasio et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(12), 2498-2507 (2013-06-25)
The anti-obesity medication rimonabant, an antagonist of cannabinoid type-1 (CB(1)) receptor, was withdrawn from the market because of adverse psychiatric side effects, including a negative affective state. We investigated whether rimonabant precipitates a negative emotional state in rats withdrawn from
Jean-François Bouchard et al.
Life sciences, 72(16), 1859-1870 (2003-02-15)
The aim of the present study was to assess the contribution of endogenous cannabinoids in the protective effect of ischemic preconditioning on the endothelial function in coronary arteries of the rat. Isolated rat hearts were exposed to a 30-min low
Rodrigo Del Rio et al.
Frontiers in synaptic neuroscience, 15, 1176864-1176864 (2023-05-30)
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to neurophysiological and behavioral abnormalities in humans. The main neuronal receptor for Δ9-tetrahydrocannabinol (THC) is the type-1 cannabinoid receptor CB1R, one of the most abundant G-protein-coupled receptors in
Talita H Ferreira-Vieira et al.
Hippocampus, 24(1), 79-88 (2013-10-12)
It is well known that physical exercise has positive effects on cognitive functions and hippocampal plasticity. However, the underlying mechanisms have remained to be further investigated. Here we investigated the hypothesis that the memory-enhancement promoted by physical exercise relies on
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