218761
Caspase-9 Inhibitor I - Calbiochem
Caspase-9 Inhibitor I, CAS 210345-04-3, is a potent, cell-permeable, and irreversible inhibitor of caspase-9.
别名:
Caspase-9 Inhibitor I - Calbiochem, Z-LE(OMe)HD(OMe)-FMK
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white to light brown
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A potent, cell-permeable, and irreversible inhibitor of caspase-9.
This product has been discontinued.
A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/72 µl) solution of Z-LEHD-FMK (Cat. No. 218841) in DMSO is also available.
Biochem/physiol Actions
Primary Target
caspase-4, caspase-5, caspase-9
caspase-4, caspase-5, caspase-9
Product does not compete with ATP.
Reversible: no
Cell permeable: yes
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Analysis Note
single spot by TLC
Other Notes
Fadeel, B., et al. 1999. Leukemia 13, 719.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Z-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
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Frank A Schildberg et al.
Cell and tissue research, 320(1), 91-98 (2005-02-17)
The possible protection provided by enhancement of the cAMP signal in the process of lipopolysaccharide (LPS)-induced endothelial cell death has been addressed, with special emphasis on the endoplasmic initiation of caspase-12-mediated apoptosis. Human umbilical vein endothelial cells were challenged with
W D Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 165(10), 5612-5620 (2000-11-09)
Past studies have shown that TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis in a high proportion of cultured melanoma by caspase-dependent mechanisms. In the present studies we have examined whether TRAIL-induced apoptosis of melanoma was mediated by direct activation of effector
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