219393
Cathepsin S Inhibitor - Calbiochem
Cathepsin S Inhibitor is a slow, tight-binding reversible inhibitor of cathepsin S (Ki = 185 pM). Exhibits 410-fold greater selectivity over cathepsin B (Ki = 76 nM).
别名:
Cathepsin S Inhibitor - Calbiochem, Z-FL-COCHO
assay
≥95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
pale yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A dipeptidyl α-keto-β-aldehyde that acts as a slow, tight-binding, highly potent, reversible inhibitor of cathepsin S. Exhibits over 410-fold greater selectivity for cathepsin S (Ki = 185 pM) over cathepsin B (Ki = 76 nM).
A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
cathepsin S
cathepsin S
Product does not compete with ATP.
Reversible: yes
Target Ki: 185 pM against cathepsin S
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Walker, B., et al. 2000. Biochem. Biophys. Res. Commun.275, 401.
Z-Phe-Leu-COCHO • H₂O
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
监管及禁止进口产品
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