产品名称
Collagen, Type I, Human Skin,
生物来源
human skin
质量水平
方案
≥95% (SDS-PAGE)
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
dilution
(compatible for the preparation of collagen gels)
杂质
≤0.1% subdermal hair
溶解性
acetic acid: 5 mg/mL (0.5M)
运输
ambient
储存温度
2-8°C
一般描述
Collagen type 1 is a fibrillar collagen present abundantly in skin, bone, vasculature, and calcified tissues of teeth and bone. It is also seen in organs like the heart and lungs. Collagen type 1 is a heterotrimer consisting of two α1 (CIα1) and one α2 (CIα2) chains with a helical region made of repeating units of proline and hydroxyproline.
应用
Collagen Type I, Human Skin has been used as a skin protein to study the effect of age-related NADH oxidase (ar-NOX)-catalyzed oxidation on skin proteins. It has also been used as a control sample in High-resolution mass spectrometry (HRMS) analysis.
生化/生理作用
Collagen type 1 is a main component of the dermal extracellular matrix (ECM) and participates in skin elasticity. Mutations in collagen type 1 are associated with osteogenesis imperfecta and Ehlers–Danlos syndrome.
外形
Salt-free.
制备说明
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
The recommended concentration is 0.01 to 0.5 M Acetic Acid (or another acidic buffer), with a maximum concentration of 5 mg/ml. The product has been tested at 0.5 M Acetic Acid and is stable for 1 month at 2-8°C. After reconstitution, aliquot and freeze at -20°C. Stock solutions remain stable for up to 6 months at this temperature.
其他说明
Gallop, P.M., and Siefert, S. 1963. Methods Enzymol. 6, 635.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin.
R Gref et al.
Scientific reports, 10(1), 16883-16883 (2020-10-11)
Vitamin C (Vit C) benefits to human skin physiology notably by stimulating the biosynthesis of collagen. The main cutaneous collagens are types I and III, which are less synthesized with aging. Vit C is one of the main promotors of
structure, function, and biomarkers
Biochemistry of Collagens, Laminins and Elastin (2019)
Collagen type I as a ligand for receptor-mediated signaling
Frontiers in physics, 5, 12-12 (2017)
Xing Xu et al.
BMC biotechnology, 11, 69-69 (2011-06-28)
Collagens require the hydroxylation of proline (Pro) residues in their triple-helical domain repeating sequence Xaa-Pro-Gly to function properly as a main structural component of the extracellular matrix in animals at physiologically relevant conditions. The regioselective proline hydroxylation is catalyzed by
Christiaan Meadows et al.
Archives of dermatological research, 306(7), 645-652 (2014-06-08)
Age-related NADH oxidase (arNOX), a cell surface-located hydroquinone oxidase capable of superoxide generation, appears at age 30 and increases with age thereafter. The ectodomain of arNOX is shed from the cell surface into body fluids including sera and saliva where
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持