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Merck
CN

324841-M

Sigma-Aldrich

EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem

别名:

EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem, 1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII, PDGFR Tyrosine Kinase Inhibitor XIII, 1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828

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关于此项目

经验公式（希尔记法）:
C18H18Cl2N6O
化学文摘社编号:
1135256-66-4
分子量:
405.28
UNSPSC代码:
12352200

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方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

pale yellow

溶解性

ethanol: 1 mg/mL
DMSO: 25 mg/mL

储存温度

2-8°C

一般描述

This product has been discontinued.



A cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.

A cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Hamby, J.M., et al. 1997. J. Med. Chem.40, 2296.
Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther.281, 1446.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

10-13 - German Storage Class 10 to 13

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