A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC₅₀ = 3 μM) but had no effect on the processing of H-Ras even at concentrations of 15 μM. Also arrests cells in the G₀/G₁ phase of the cell cycle, induces apoptosis and enhances nitric oxide synthase-2 induction by IL-1β.

A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC₅₀ = 3 μM) but has no effect on the processing of H-Ras even at concentrations of 15 μM. Inhibits PDGF-receptor tyrosine phosphorylation. Also arrests cells in the G₀/G₁ phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β.

A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.

Target IC₅₀:3 μM against processing of Rap 1A

Supplied as a trifluoroacetate salt.

Degas DMSO just prior to reconstitution

Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.