Merck
CN
所有图片(1)

文件

400046

Sigma-Aldrich

Hydroxyurea

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

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别名:
Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I
经验公式（希尔记法）:
CH4N2O2
CAS号:
127-07-1
分子量:
76.05
MDL编号:
MFCD00007943
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

water: 5 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChI key

VSNHCAURESNICA-UHFFFAOYSA-N

一般描述

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

生化/生理作用

Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

其他说明

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340 - H361

危险分类

Muta. 1B - Repr. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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