400046
Hydroxyurea
≥98% (HPLC), solid, RNR inhibitor, Calbiochem
别名:
Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I
Product Name
Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
质量水平
描述
Merck USA index - 14, 4848
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
water: 5 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
N(O)C(=O)N
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
一般描述
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.
生化/生理作用
Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no
制备说明
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
其他说明
Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Carcinogenic / Teratogenic (D)
警示用语：
Danger
危险声明
危险分类
Muta. 1B - Repr. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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