方案
≥98% (SDS-PAGE and HPLC)
质量水平
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
杂质
≤0.1 ng/μg Endotoxins
运输
wet ice
储存温度
−20°C
一般描述
Full-length, recombinant, human insulin-like growth factor I (IGFI) expressed in E. coli. The IGFI growth factor regulates proliferation and survival signals through the AKT pathway. This animal free growth hormone is useful in the study of cell proliferation and survival signals.
生化/生理作用
ED ₅₀: ≤1 ng/ml as determined by a cell proliferation assay using FDC-P1 cells; this corresponds to a specific ≥1 x 10⁶ units/mg.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Reconstitute with H₂O to a final concentration of 0.1-1 mg/ml. Further dilute with physiological buffer prior to use.
其他说明
Stabnov, L., et al. 2002. Bone30, 909.
Devireddy, L.R., et al. 2001. Science 293, 829.
Chen, C.W., and Ray, D. 1995. Carcinogenesis 16, 1339.
Devireddy, L.R., et al. 2001. Science 293, 829.
Chen, C.W., and Ray, D. 1995. Carcinogenesis 16, 1339.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Longxing Cao et al.
Nature, 605(7910), 551-560 (2022-03-26)
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1-5. Here we describe a general solution to this problem
Blaz Lupse et al.
Cell reports, 36(5), 109490-109490 (2021-08-05)
Pancreatic β-cell failure is the key pathogenic element of the complex metabolic deterioration in type 2 diabetes (T2D); its underlying pathomechanism is still elusive. Here, we identify pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 (PHLPP1/2) as phosphatases
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