416154
Isoginkgetin
≥98% (HPLC), solid, pre-mRNA splicing inhibitor, Calbiochem®
别名:
前体mRNA剪接抑制剂，异银杏双黄酮
产品名称
前体mRNA剪接抑制剂，异银杏双黄酮, The Pre-mRNA Splicing Inhibitor, Isoginkgetin, also referenced under CAS 548-19-6, blocks the spliceosome-meidated splicing process.
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[o]1c2c([c](cc1c6ccc(cc6)OC)=O)c(cc(c2c3c(ccc(c3)c4[o]c5c([c](c4)=O)c(cc(c5)O)O)OC)O)O
InChI
1S/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3
InChI key
HUOOMAOYXQFIDQ-UHFFFAOYSA-N
相关类别
一般描述
一种细胞可渗透的，天然分离的银杏双黄酮类化合物，通过在前剪接体/A复杂阶段阻断对剪接体介导的剪接过程，作为一般的前mRNA剪接抑制剂（在使用HeLa核提取物的剪接测定中，ICmax = 50 µM）。已显示异银杏素治疗以可逆的方式导致HEK293衍生的培养物中的生长停滞，而不会影响细胞活率（33 µM持续24 h）。
天然分离的银杏双黄酮类化合物，通过阻止前剪接体A复合物募集U4/U5/U6 tri-snRNP（稳定的核RNA及其相关蛋白）形成B复合物，作为剪接体介导的前mRNA剪接的细胞可渗透，可逆抑制剂（在使用HeLa核提取物的剪接测定中，IC50和ICmax分别为30和50 µM）。已显示异银杏素治疗以可逆的方式导致HEK293衍生的培养物中的生长停滞，而不会影响细胞活率（33 µM持续24 h）。
包装
用惰性气体包装
其他说明
Kim, H.Y., et al. 2008.Arch.Pharm. Res.31, 265.
O′Brien, K., et al. 2008.J. Biol. Chem.283, 33147.
Yoon, S,O., et al. 2006.Mol.Cancer Ther.5, 2666.
O′Brien, K., et al. 2008.J. Biol. Chem.283, 33147.
Yoon, S,O., et al. 2006.Mol.Cancer Ther.5, 2666.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Wenbo Zhu et al.
ACS omega, 5(39), 25306-25311 (2020-10-13)
Deposition and dysfunction of U1 small nuclear ribonucleoprotein (snRNP) have been revealed in Alzheimer's disease (AD), but whether U1 is involved in the amyloid precursor protein (APP) and Tau pathways remains unclear. Here, we investigate this by inhibiting the U1
Hyun Pyo Kim et al.
Archives of pharmacal research, 31(3), 265-273 (2008-04-15)
Biflavonoids belong to a subclass of the plant flavonoid family. Distribution of biflavonoids in the plant kingdom is limited to several species. Previously, some pharmacological activities of biflavonoids were described such as inhibition of histamine release from mast cells and
Kristine O'Brien et al.
The Journal of biological chemistry, 283(48), 33147-33154 (2008-10-02)
Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been
Sang-Oh Yoon et al.
Molecular cancer therapeutics, 5(11), 2666-2675 (2006-11-24)
Matrix metalloproteinase (MMP)-9 plays a key role in tumor invasion. Inhibitors of MMP-9 were screened from Metasequoia glyptostroboides (Dawn redwood) and one potent inhibitor, isoginkgetin, a biflavonoid, was identified. Noncytotoxic levels of isoginkgetin decreased MMP-9 production profoundly, but up-regulated the
Lauren Duan et al.
Cell reports, 40(3), 111106-111106 (2022-07-21)
Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration and an important therapeutic target. Our current understanding of TDP-43 nucleocytoplasmic transport does not fully explain its predominantly nuclear localization or mislocalization in disease. Here, we show that
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