444144
MDM2 Antagonist II, NSC 66811
The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.
别名:
MDM2 Antagonist II, NSC 66811, 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
储存温度
2-8°C
InChI
1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChI key
WEENRMPCSWFMTE-UHFFFAOYSA-N
一般描述
A cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.
生化/生理作用
Cell permeable: yes
Primary Target
MDM2
MDM2
Product does not compete with ATP.
Target Ki: 120 nM against MDM2
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Lu, Y., et al. 2006. J. Med. Chem.49, 3759.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Yipin Lu et al.
Journal of medicinal chemistry, 49(13), 3759-3762 (2006-06-23)
An integrated, virtual database screening strategy has led to 7-[anilino(phenyl)methyl]-2-methyl-8-quinolinol (4, NSC 66811) as a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. This quinolinol binds to MDM2 with a Ki of 120 nM and activates p53 in
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持