459620
Okadaic Acid sodium salt
≥98% (TLC), solid,film (colorless), protein phosphatase 2A and protein phosphatase 1 inhibitor, Calbiochem®
别名:
冈田酸，钠盐
产品名称
冈田酸，钠盐, Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
water: 1 mg/mL
DMSO: 20 mg/mL
ethanol: 20 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：蛋白磷酸酶1、蛋白磷酸酶2A分别为10-15 nM、0.1 nM
Disclaimer
毒性：有毒（F）
General description
冈田酸的水溶性类似物（目录号495604）。抑制蛋白磷酸酶1和2A。
Other Notes
Gjertsen, B.T., et al. 1994.J. Cell Sci.107, 3363.
Kiguchi, K., et al. 1994.Cell Growth Differentiation5, 995.
Ohaka, Y., et al. 1993.Biochem.Biophys.Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992.Biochem.Biophys.Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992.Blood80, 2911.
Normura, M., et al. 1992.Biochemistry31, 11915.
Song, Q., et al. 1992.J. Cell Physiol.153, 550.
Tada, Y., et al. 1992.Immunopharmacol.24, 17.
Cohen, P., et al. 1990.Trends Biochem.Sci.15, 98.
Cohen, P. 1989.Annu.Rev. Biochem.58, 453.
Cohen, P., and Cohen, P.T.W.1989.J. Biol. Chem.254 21435.
Haystead, T.A. et al. 1989.Nature337, 78.
Kiguchi, K., et al. 1994.Cell Growth Differentiation5, 995.
Ohaka, Y., et al. 1993.Biochem.Biophys.Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992.Biochem.Biophys.Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992.Blood80, 2911.
Normura, M., et al. 1992.Biochemistry31, 11915.
Song, Q., et al. 1992.J. Cell Physiol.153, 550.
Tada, Y., et al. 1992.Immunopharmacol.24, 17.
Cohen, P., et al. 1990.Trends Biochem.Sci.15, 98.
Cohen, P. 1989.Annu.Rev. Biochem.58, 453.
Cohen, P., and Cohen, P.T.W.1989.J. Biol. Chem.254 21435.
Haystead, T.A. et al. 1989.Nature337, 78.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
P Kreienbühl et al.
Blood, 80(11), 2911-2919 (1992-12-01)
The phosphatase inhibitors okadaic acid and calyculin A were found to elicit or to modify several neutrophil responses, suggesting that dephosphorylation plays a regulatory role. The concentrations of okadaic acid (> or = 1 mumol/L) that were effective on neutrophil
R Gopalakrishna et al.
Biochemical and biophysical research communications, 189(2), 950-957 (1992-12-15)
The cell-permeable inhibitors of type 1 and 2A protein phosphatases, okadaic acid and calyculin-A, induced a redistribution of protein kinase C (PKC) activity and immunoreactivity (40 to 60%) from cytosol to membrane in some cell types. Calyculin-A was 100-fold more
Y Ohoka et al.
Biochemical and biophysical research communications, 197(2), 916-921 (1993-12-15)
Glucocorticoids induce apoptosis in murine T cell hybridomas. It was inhibited by okadaic acid and calyculin A, potent inhibitors of protein phosphatase 1 and 2A, but not by 1-norokadaone, a structural analog of okadaic acid without phosphatase inhibitory activity. The
Q Song et al.
Journal of cellular physiology, 153(3), 550-556 (1992-12-01)
Gamma-radiation, tetrandrine, bistratene A, and cisplatin were all found to induce pronounced morphological changes characteristic of apoptosis and extensive DNA fragmentation in the human BM13674 cell line 8 h after treatment. Apoptosis induced in BM13674 cells by these diverse agents
Protein phosphatases come of age.
P Cohen et al.
The Journal of biological chemistry, 264(36), 21435-21438 (1989-12-25)
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