475825
mitoNEET Inhibitor NL-1, Thiazolidinedione
The mitoNEET Inhibitor NL-1, Thiazolidinedione controls the biological activity of mitoNEET.
别名:
mitoNEET Inhibitor NL-1, Thiazolidinedione, 5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
yellow
溶解性
DMSO: 100 mg/mL, clear, pale yellow
运输
ambient
储存温度
−20°C
一般描述
A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50 = 0.9 µM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4 µM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25 µM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Geldenhuys, W.J., et al. 2009. Bioorg Med Chem Lett.3, 819.
Giles, R.G., et al. 2000. Tetrahedron56, 4531.
Giles, R.G., et al. 2000. Tetrahedron56, 4531.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Seunghee Lee et al.
Cell death & disease, 13(2), 127-127 (2022-02-10)
MitoNEET (mitochondrial protein containing Asn-Glu-Glu-Thr (NEET) sequence) is a 2Fe-2S cluster-containing integral membrane protein that resides in the mitochondrial outer membrane and participates in a redox-sensitive signaling and Fe-S cluster transfer. Thus, mitoNEET is a key regulator of mitochondrial oxidative
Aitor Martinez et al.
Molecular neurodegeneration, 19(1), 12-12 (2024-01-26)
Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Functional analysis of genes linked to PD have revealed that the E3 ligase Parkin and the
Kamalakannan Vijayan et al.
Cell chemical biology, 29(9), 1419-1433 (2022-06-24)
Prior to initiating symptomatic malaria, a single Plasmodium sporozoite infects a hepatocyte and develops into thousands of merozoites, in part by scavenging host resources, likely delivered by vesicles. Here, we demonstrate that host microtubules (MTs) dynamically reorganize around the developing
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