475880
ML-7 Hydrochloride
>98% (TLC), protein kinase A and C inhibitor, solid
别名:
ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
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关于此项目
经验公式（希尔记法）:
C15H17IN2O2S · xHCl
化学文摘社编号:
分子量:
416.28 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
盐酸 ML-7-CAS 110448-33-4-Calbiochem, A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).
SMILES string
Ic1c2c(c(ccc2)[S](=O)(=O)N3CCNCCC3)ccc1
InChI
1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
InChI key
GEHJIACZUFWBTK-UHFFFAOYSA-N
assay
>98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
50% ethanol: 4.5 mg/mL
DMSO: 4.5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Myosin light chain kinase (Mlck)
Product competes with ATP.
Reversible: yes
Target Ki: 300 nM against myosin light chain kinase
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.
Other Notes
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Further dilute with aqueous buffer just prior to use.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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