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Merck
CN

476480

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

别名:

PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH2, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH2, Protein Kinase C 20-28, Cell-Permeable, Myristoylated

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关于此项目

经验公式（希尔记法）:
C60H106N18O11
分子量:
1255.60
UNSPSC Code:
12352200

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assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 10 mg/mL, Tris-HCl, pH 7.5: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC50 = 8 µM); exhibits 98% inhibition at 100 µM.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures
Product does not compete with ATP.
Reversible: yes
Target IC50: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Packaging

Yes

Other Notes

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.
N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Carsten Riether et al.
Cell reports, 34(4), 108663-108663 (2021-01-28)
Self-renewal is a key characteristic of leukemia stem cells (LSCs) responsible for the development and maintenance of leukemia. In this study, we identify CD93 as an important regulator of self-renewal and proliferation of murine and human LSCs, but not hematopoietic

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