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Merck
CN

476480

Sigma-Aldrich

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

别名:

PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH₂, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH₂, Protein Kinase C 20-28, Cell-Permeable, Myristoylated

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关于此项目

经验公式（希尔记法）:
C60H106N18O11
分子量:
1255.60
UNSPSC代码:
12352200

主要文件

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质量水平

100

方案

≥95% (HPLC)

表单

lyophilized solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

溶解性

water: 10 mg/mL
Tris-HCl, pH 7.5: 25 mg/mL

运输

ambient

储存温度

−20°C

一般描述

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC50 = 8 µM); exhibits 98% inhibition at 100 µM.

生化/生理作用

Cell permeable: yes
Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures
Product does not compete with ATP.
Reversible: yes
Target IC50: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

包装

Yes

其他说明

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.
N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Carsten Riether et al.
Cell reports, 34(4), 108663-108663 (2021-01-28)
Self-renewal is a key characteristic of leukemia stem cells (LSCs) responsible for the development and maintenance of leukemia. In this study, we identify CD93 as an important regulator of self-renewal and proliferation of murine and human LSCs, but not hematopoietic

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