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476485

PKA Inhibitor 14-22 Amide

Name: PKA Inhibitor 14-22 Amide
Brand: MM

≥95% (HPLC), PKA Inhibitor, lyophilized

别名:

PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化

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关于此项目

经验公式（希尔记法）:

C₅₃H₁₀₀N₂₀O₁₂

分子量:

1209.49

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

lyophilized

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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产品名称

PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化, PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (K_i = 36 nM).

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶（PKA）的高度特异性抑制剂（K_i=36 nM）。

Biochem/physiol Actions

主要靶标
cAMP依赖性蛋白激酶

产物不与ATP竞争。

可逆：否

细胞可渗透性：具有

靶标K_i：36 nMf或cAMP依赖性蛋白激酶

Physical form

作为三氟乙酸盐提供。

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。

Other Notes

Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂

Paman, K., et al. 1998.J. Lipid Res. 39, 1091.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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货号	GTIN
476485-500UG	04055977183832

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