Product Name
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化, PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM).
质量水平
方案
≥95% (HPLC)
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
溶解性
water: 1 mg/mL
运输
ambient
储存温度
−20°C
相关类别
一般描述
热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶（PKA）的高度特异性抑制剂（Ki=36 nM）。
生化/生理作用
主要靶标
cAMP依赖性蛋白激酶
cAMP依赖性蛋白激酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标Ki：36 nMf或cAMP依赖性蛋白激酶
外形
作为三氟乙酸盐提供。
制备说明
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他说明
Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
Paman, K., et al. 1998.J. Lipid Res. 39, 1091.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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