跳转至内容
Merck
CN

5.05897

(±)-PD 128907 Hydrochloride - CAS 112960-16-4 - Calbiochem

别名:

(±)-PD 128907 Hydrochloride - CAS 112960-16-4 - Calbiochem

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C14H19NO3 · xHCl
化学文摘社编号:
112960-16-4
分子量:
249.31 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00210210

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

assay

≥98% (HPLC)

form

powder

potency

2.3 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 5 mg/mL

storage temp.

−20°C

General description

Selective dopamine D3 receptor agonist (Ki = 2.3 nM) with an 18-fold selectivity over long dopamine receptors (D2L) and exhibited only weak affinity for D4.2 receptors (Ki = 169 nM). Commonly used to reproduce cocaine′s discriminative stimulus effects and also in peripheral systemic studies of hypertension.

Biochem/physiol Actions

Primary Target
D₃

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Achat-Mendes, c. et al. 2010. J. Pharmacol. Exp. Ther.334, 556.

Zeng, C. et al. 2006. Circul. Res.99, 494.

Pugsley, T. A. et al. 1995. J. Pharmacol. Exp. Ther.275, 1355.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

法规信息

新产品
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

T A Pugsley et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1355-1366 (1995-12-01)
The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a dopamine (DA) receptor agonist that shows a preference for the human D3 receptor. In transfected Chinese hamster ovary cells (CHO K1), PD 128907 displaced [3H]spiperone
Chunyu Zeng et al.
Circulation research, 99(5), 494-500 (2006-08-12)
The dopaminergic and renin angiotensin systems interact to regulate blood pressure. Disruption of the D(3) dopamine receptor gene in mice produces renin-dependent hypertension. In rats, D(2)-like receptors reduce angiotensin II binding sites in renal proximal tubules (RPTs). Because the major
Cindy Achat-Mendes et al.
The Journal of pharmacology and experimental therapeutics, 334(2), 556-565 (2010-05-25)
Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized. This study investigated the role of D3 and D2 subtype mechanisms by determining

相关内容

New Products Flyer- Feb 2014 - Vol 1

"Apoptosis & Autophagy in Cancer: Cell Survival by Eluding Cell Death The ability of tumor cells to elude programmed cell death, also known as apoptosis, is a hallmark of most types of cancer. Similary, autophagy is a highly regulated, homeostatic degradative process where cells destroy their own components via the lysosomal machinery and recycle them for prolonged cell survival. Via extensive crosstalk with pro-apoptotic signaling pathways, autophagy can also contribute to cell death and greatly influence general cell health. Elucidating the correlation between autophagy and apoptotic cell death has become the focus of a great deal of research, particularly in tumor biology. On one hand, autophagy may induce cell death by degrading essential components; on the other hand, it may facilitate survival of cancer cells under unfavorable metabolic conditions."

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持