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527451

PKR Inhibitor

Name: PKR Inhibitor
Brand: MM

InSolution, ≥90%

别名:

InSolution PKR Inhibitor, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I, C16

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关于此项目

经验公式（希尔记法）:

C₁₃H₈N₄OS

化学文摘社编号:

608512-97-6

分子量:

268.29

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD06735404

Assay:

≥90% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

shipped in

dry ice

storage temp.

−20°C

SMILES string

[s]1c2c(nc1)ccc3c2\C(=C\c4nc[nH]c4)\C(=O)N3

InChI

1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-

InChI key

VFBGXTUGODTSPK-BAQGIRSFSA-N

说明

General description

An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC₅₀ = 210 nM) and rescue PKR-dependent translation block (IC₅₀ = 100 nM). The solid form of this compound (Cat. No. 527450 ) is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKR

Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450 ) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Zhu, P.J., et al. 2011. Cell147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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Small molecule inhibitors of the RNA-dependent protein kinase.

Narasimham V Jammi et al.

Biochemical and biophysical research communications, 308(1), 50-57 (2003-08-02)

The RNA-dependent protein kinase (PKR) is an interferon-induced serine/threonine protein kinase that phosphorylates the alpha subunit of the eukaryotic initiation factor 2 in response to viral infection. Classical genetic approaches for studying the role of PKR in cell signaling have

Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition.

Ping Jun Zhu et al.

Cell, 147(6), 1384-1396 (2011-12-14)

The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while

Primary T-cell-based delivery platform for in vivo synthesis of engineered proteins.

Harikrishnan Radhakrishnan et al.

Bioengineering & translational medicine, 9(1), e10605-e10605 (2024-01-09)

Primary T cell has been transformed into a cell-based delivery platform that synthesizes complex biologics at the disease site with spatiotemporal resolution. This broadly applicable technology can circumvent toxicities due to systemic administration of biologics that necessitates the use of

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全球贸易项目编号

货号	GTIN
527451-5MG	04055977270372