565610
SC-560
A cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM).
别名:
SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole
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关于此项目
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
InChI
1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChI key
PQUGCKBLVKJMNT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC50 = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC50 = 6.3 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
COX-1
COX-1
Product does not compete with ATP.
Reversible: no
Target IC50: 9 nM against COX-1
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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