γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem

A non-peptidic, cell-permeable, active site-directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β 40 (Aβ₄₀) and 42 (Aβ₄₂) in HEK293 cells (70-80% inhibition at 100 μM concentration) expressing wild-type and Swedish-mutant β-amyloid precursor protein (βAPP). Does not exhibit any significant effect on either the processing or mΔEnotch-1 or the endoproteolysis of presenilins.

The γ-Secretase Inhibitor XI controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-secretase and blocks the production of both Aβ₄₀ and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)

Target IC₅₀:< 100 μM against γ-secretase and blocks the production of both amyloid-β₄₀ (Aβ₄₀) and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)

t_1/2 = 200 min in 100 μM HEPES, 500 μM NaCl, and 10% DMSO, pH 7.5.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. This product is not stable in aqueous solution, hence, dilute in aqueous solution right prior to use (t_½ at 25°C = 3.3 h in 100 mM HEPE