575307
T113242
A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin.
别名:
T113242, T1, (4-N,Nʹ-Dimethylanilino)-pentafluorosulfonamide
质量水平
方案
≥90% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 200 mg/mL
methanol: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
Fc1c(c(c(c(c1F)F)[S](=O)(=O)Nc2ccc(cc2)N(C)C)F)F
InChI
1S/C14H11F5N2O2S/c1-21(2)8-5-3-7(4-6-8)20-24(22,23)14-12(18)10(16)9(15)11(17)13(14)19/h3-6,20H,1-2H3
InChI key
CLMSOSHEPLACPG-UHFFFAOYSA-N
一般描述
A cell-permeable pentafluorosulfonamide compound that covalently binds to β-tubulin and induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcription has been shown to be mediated by the Erk signaling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).
生化/生理作用
Cell permeable: yes
Primary Target
β-tubulin
β-tubulin
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Ziegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 458.
Ziegelbauer, J., et al. 2001. Mol. Cell8, 339.
Ziegelbauer, J., et al. 2001. Mol. Cell8, 339.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Carcinogenic / Teratogenic (D)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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