613560
TMPyP4
≥90% (TLC), solid, telomerase inhibitor, Calbiochem®
别名:
TMPyP4, meso-5,10,15,20-四-（N-甲基-4-吡啶基）卟啉，四甲苯磺酸盐
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关于此项目
经验公式（希尔记法）:
C44H38N8 · C28H28O12S4
化学文摘社编号:
分子量:
1363.60
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
产品名称
TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).
质量水平
方案
≥90% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
purple
溶解性
water: 1 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3
InChI key
AKZFRMNXBLFDNN-UHFFFAOYSA-K
相关类别
一般描述
一种有效的人类端粒酶抑制剂（IC50 = 6.5 µM）。TMPyP4通过堆叠在四链体核心的G-四联体上与DNA四链体紧密结合，导致端粒酶抑制。在四链体DNA存在下发出强烈荧光。
生化/生理作用
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
靶标IC50：6.5 µM抑制人端粒酶
其他说明
Yamashita, T., et al. 2005.Bioorg.Med. Chem.13, 2433.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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