613560
TMPyP4
≥90% (TLC), solid, telomerase inhibitor, Calbiochem®
别名:
TMPyP4, meso-5,10,15,20-四-（N-甲基-4-吡啶基）卟啉，四甲苯磺酸盐
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关于此项目
经验公式（希尔记法）:
C44H38N8 · C28H28O12S4
化学文摘社编号:
分子量:
1363.60
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
TMPyP4, A potent inhibitor of human telomerase (IC50 = 6.5 µM).
InChI
1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3
InChI key
AKZFRMNXBLFDNN-UHFFFAOYSA-K
assay
≥90% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
purple
solubility
water: 1 mg/mL
shipped in
ambient
Quality Level
General description
一种有效的人类端粒酶抑制剂（IC50 = 6.5 µM）。TMPyP4通过堆叠在四链体核心的G-四联体上与DNA四链体紧密结合，导致端粒酶抑制。在四链体DNA存在下发出强烈荧光。
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
靶标IC50：6.5 µM抑制人端粒酶
Other Notes
Yamashita, T., et al. 2005.Bioorg.Med. Chem.13, 2433.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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