662009
U0126
≥98% (HPLC), MEK1 inhibitor, liquid
别名:
InSolution U0126
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关于此项目
经验公式（希尔记法）:
C18H16N6S2 · 0.5C2H6O
化学文摘社编号:
分子量:
403.52
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
U0126, InSolution, ≥98%, A potent and specific inhibitor of MEK1 and MEK2
SMILES string
S(c2c(cccc2)N)\C(=C(\C(=C(\Sc1c(cccc1)N)/N)\C#N)/C#N)\N
InChI
1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChI key
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
shipped in
ambient
storage temp.
−70°C
Quality Level
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General description
A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
Packaging
Packaged under inert gas
Physical form
A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
Preparation Note
Following initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
Other Notes
Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett.8, 2839.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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