662141
PR-619
≥99% (HPLC), solid, DUB inhibitor, Calbiochem®
别名:
DUB抑制剂V，PR-619, UCH-L3抑制剂II，UCH-L5/UCH37抑制剂III，USP5抑制剂II，USP7抑制剂I，USP9X抑制剂II，USP14抑制剂IV，USP14抑制剂IV，USP47抑制剂I，2,6-二氨基吡啶-3,5-双（硫氰酸盐），3,5-二硫氰基吡啶-2,6-二胺，PR619，UC
Product Name
DUB抑制剂V，PR-619, The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
质量水平
方案
≥99% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light beige to yellow
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
相关类别
一般描述
一种细胞渗透性吡啶胺类广谱DUB抑制剂，其已知靶标包括ATXN3、BAP1、JOSD2、OTUD5、UCH-L1、UCH-L3、UCH-L5/UCH37、USP1、2、4、5、7、8、9X、10、14、15、16、19、20、22、24、28、47、48、VCIP135、YOD1，以及deISGylase PLpro、deNEDDylase DEN1和deSUMOlyase SENP6。PR-619和P22077（目录号662142）均显示以剂量和时间依赖性方式（20至150 µM；0.5至20 h）增加HEK293T细胞中的整体蛋白多聚泛素化，然而P22077暴露主要导致K48连接的富集，而PR619处理导致K48和K63连接的多聚亚基链的上调。
包装
用惰性气体包装
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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相关内容
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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