biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, mouse, bovine, human
manufacturer/tradename
Chemicon®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GABRB2(2561)
Immunogen
来自大鼠GABAA受体β2亚基胞质环的MBP融合蛋白。
Application
抗GABA A受体β2抗体，细胞质环是用于IP&WB的针对GABA A受体β2的抗体。
蛋白质印迹：1：1,000
免疫沉淀：使用15 μg抗体，该抗体可免疫沉淀大鼠前脑（150μ L）十二烷基硫酸盐提取物中68%的全部GABAA受体。
最佳工作稀释度必须由最终用户进行确定。
免疫沉淀：使用15 μg抗体，该抗体可免疫沉淀大鼠前脑（150μ L）十二烷基硫酸盐提取物中68%的全部GABAA受体。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
GABAA受体β2亚基。该抗体对大鼠脑膜组分中的〜50至56kDa具有特异性。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
Evangelos Sotiriou et al.
Journal of neuroscience research, 82(5), 690-700 (2005-11-08)
Recent data demonstrate weaker gamma-aminobutyric acid (GABA)-ergic inhibition in ventral (VH) compared with dorsal (DH) hippocampus. Therefore, we examined possible differences regarding the GABAA receptors between VH and DH as follows: 1) the expression of the GABAA receptor subunits (alpha1/2/4/5
Zechun Peng et al.
Neurochemical research, 39(6), 1104-1117 (2013-12-20)
The α4 subunit of the GABAA receptor (GABAAR) is highly expressed in the thalamus where receptors containing the α4 and δ subunits are major mediators of tonic inhibition. The α4 subunit also exhibits considerable plasticity in a number of physiological
GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors.
Ding, L; Feng, HJ; Macdonald, RL; Botzolakis, EJ; Hu, N; Gallagher, MJ
The Journal of Biological Chemistry null
George E Farmer et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 315(5), R972-R982 (2018-08-30)
The median preoptic nucleus (MnPO) is an integrative site involved in body fluid homeostasis, cardiovascular control, thermoregulation, and sleep homeostasis. Angiotensin II (ANG II), a neuropeptide shown to have excitatory effects on MnPO neurons, is of particular interest with regard
Jingjing Duan et al.
Frontiers in cellular neuroscience, 13, 217-217 (2019-06-25)
In the adult brain GABAA receptors (GABAARs) mediate the majority of synaptic inhibition that provides inhibitory balance to excitatory drive and controls neuronal output. In the immature brain GABAAR signaling is critical for neuronal development. However, the cell-autonomous role of
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