biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pSer421)
Quality Level
Gene Information
human ... HTT(3064), SLC6A4(6532)
Immunogen
来自人亨廷顿蛋白蛋白的合成肽。 由于免疫原序列的保守性，预测抗体可能会与大鼠和小鼠发生交叉反应（8/9）。
表位：磷酸化Ser 421
Application
可使用这种亨廷顿蛋白抗体（磷酸化Ser 421）检测亨廷顿蛋白，该抗体经验证可用于WB。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
蛋白质印迹：使用ECL为1：500-1：3,000可与未经刺激的人PC-3全细胞裂解液中的~190 kD亨廷顿蛋白反应。还能检测到~130处的其他条带。
ELISA：1:10,000-1:40,000
最佳工作稀释度必须由最终用户确定。
ELISA：1:10,000-1:40,000
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
可识别在丝氨酸421处磷酸化的亨廷顿蛋白。预计与该蛋白的非磷酸化形式的反应性很小。
Physical form
亲和纯化的免疫球蛋白。溶液，溶于含0.01%叠氮化钠的0.02M磷酸钾、0.25M氯化钠。
Preparation Note
自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。 应避免反复冻/融循环。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Hélène Vitet et al.
eLife, 12 (2023-07-11)
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains a pool of SVs, only a small fraction of which are released, it has been
Adriana Covarrubias-Pinto et al.
Journal of neuroscience research, 99(1), 223-235 (2020-08-06)
Huntington's disease (HD) is a neurodegenerative disorder caused by a glutamine expansion at the first exon of the huntingtin gene. Huntingtin protein (Htt) is ubiquitously expressed and it is localized in several organelles, including endosomes. HD is associated with a
Kirstie H Stansfield et al.
Toxicological sciences : an official journal of the Society of Toxicology, 127(1), 277-295 (2012-02-22)
Dysregulation of synaptic development and function has been implicated in the pathophysiology of neurodegenerative disorders and mental disease. A neurotrophin that has an important function in neuronal and synaptic development is brain-derived neurotrophic factor (BDNF). In this communication, we examined
Kirstie H Stansfield et al.
Journal of neurochemistry, 131(5), 655-666 (2014-08-08)
High levels of manganese (Mn) exposure decrease striatal medium spiny neuron (MSN) dendritic length and spine density, but the mechanism(s) are not known. The Huntingtin (HTT) gene has been functionally linked to cortical brain-derived neurotrophic factor (BDNF) support of striatal
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