Anti-LRRTM2 Antibody

Leucine-rich repeat transmembrane neuronal protein 2, also known as Leucine-rich repeat neuronal 2 protein, and encoded by the gene name LRRTM2 or LRRN2, is involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development

Epitope: cytoplasmic domain

KLH-conjugated synthetic peptide corresponding to the cytoplasmic domain of human LRRTM2.

Anti-LRRTM2 Antibody detects level of LRRTM2 & has been published & validated for use in LRRTM2.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected LRRTM2 in human brain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Evaluated by Western Blotting in SK-N-SH cell lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected LRRTM2 in SK-N-SH cell lysate.

~65 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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