ABT131
Anti-PTRF/cavin-1 Antibody
from rabbit, purified by affinity chromatography
别名:
Polymerase I and transcript release factor, Cavin-1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat, human
species reactivity (predicted by homology)
bovine (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CAVIN1(284119)
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General description
Polymerase I and transcript release factor (PTRF), also known as “cavin-1,” is a small cytoplasmic protein, which interacts with caveolin-1 to assemble specialized membrane invaginations (or caveolae), in various types of cells. Caveolae house specific proteins and lipids and play a central role in cell signaling and endocytosis. PTRF may also play a role in metabolism. Mice lacking functional PTRF are affected by hyperinsulinemia and glucose intolerance. In addition, PTRF may play a role in prostate cancer.
~60 kDa, ~43 kDa observed. Three isoforms at 43 kDa, 33 kDa, and 23 kDa are known to exist. This protein was observed at ~60 kDa by an independent laboratory due to post-translational modification (Hill, M. M., et al. (2008). Cell. 132(1):113-124.).
Immunogen
KLH-conjugated linear peptide corresponding to the Coiled Coil domain of human PTRF/cavin-1.
Application
Anti-PTRF/cavin-1 Antibody detects level of PTRF/cavin-1 & has been published & validated for use in Western Blotting, IHC(P).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected PTRF/cavin-1 in mouse cardiac tissue and mouse alveoli tissue.
Biochem/physiol Actions
This antibody recognizes the Coiled Coil domain of PTRF/cavin-1.
Analysis Note
Evaluated by Western Blot in human lung tissue lysate.
Western Blot Analysis: 1 mg/mL of this antibody detected PTRF/cavin-1 in 10 mg of human lung tissue lysate.
Western Blot Analysis: 1 mg/mL of this antibody detected PTRF/cavin-1 in 10 mg of human lung tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Michael L De Ieso et al.
Frontiers in cell and developmental biology, 10, 855097-855097 (2022-04-05)
Polymorphisms in the CAV1/2 gene loci impart increased risk for primary open-angle glaucoma (POAG). CAV1 encodes caveolin-1 (Cav1), which is required for biosynthesis of plasma membrane invaginations called caveolae. Cav1 knockout mice exhibit elevated intraocular pressure (IOP) and decreased outflow
Maider Varela-Guruceaga et al.
Frontiers in physiology, 11, 565486-565486 (2020-12-17)
Repetitive complete or incomplete pharyngeal collapses are leading to chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA) syndrome responsible for many metabolic disorders. In humans, an association between OSA and insulin resistance has been found independently
Yin Shi et al.
Autophagy, 11(5), 769-784 (2015-05-07)
CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein of caveolae, a specialized plasma membrane structure. Relatively, the caveolae-independent function of CAV1 is less studied. Autophagy is a process known to involve various membrane structures
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