species reactivity
human
Quality Level
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
assay range
accuracy: 87%
(MIP-1β), accuracy: 92%
(MIP-1α), accuracy: 95%
(Granzyme B), accuracy: 98%
(IL-8), standard curve range: 10-10,000 pg/mL
(IL-1α and MIP-1β), standard curve range: 195-200,000 pg/mL
(MMP-8), standard curve range: 2,930-3,000,000 pg/mL
(HSP70), standard curve range: 2-2,000 pg/mL
(Granzyme B), standard curve range: 5-5,000 pg/mL
(IL-8 and MIP-1β)
technique(s)
multiplexing: suitable
input
serum
cell culture supernatant
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
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General description
Application
Analytes included: Granzyme B, HSP70, IL-1α, IL-8, MIP-1α, MIP-1β, MMP-8
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
- Immune Response Research Panel: Luminex® xMAP® platform simultaneously quantitates 7 critical immune response biomarkers (Granzyme B, HSP70, IL-1α, IL-8/CXCL8, MIP-1α/CCL3, MIP-1β/CCL4, MMP-8) for comprehensive sepsis immunology research.
- Streamlined Sample Processing: Compatible with human serum, plasma, and cell/tissue culture supernatants using neat sample analysis - no dilution required, simplifying research protocols and minimizing sample handling errors.
- Multi-Pathway Sepsis Research: Investigate cytotoxic T-cell responses (Granzyme B), cellular stress (HSP70), pro-inflammatory cytokines (IL-1α, IL-8), chemokine signaling (MIP-1α, MIP-1β), and tissue remodeling (MMP-8) in sepsis pathogenesis studies.
- Comprehensive Immune Profiling: Simultaneously measure innate immune activation, adaptive immune responses, chemotactic signals, and tissue damage markers to understand complex sepsis immunopathology in research settings.
- Translational Sepsis Research: Address critical research gaps in understanding sepsis progression from initial immune response through SIRS, severe sepsis, and potential progression to MODS in experimental studies.
- Flexible Research Applications: Configure analyte selection for specific research questions and adapt to various experimental designs from mechanistic cell culture studies to clinical research sample analysis.
Legal Information
Disclaimer
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
法规信息
相关内容
Immunology multiplex assays, like MILLIPLEX® assays, allow researchers to investigate more immune biomarkers simultaneously, saving time and resources.
See how multiplexing the inflammation signaling pathway with MILLIPLEX® inflammation assays or cell signaling assays can help researchers bridge the gap between immunology and cell signaling, including investigating T cell signaling, Th Cell differentiation, inflammatory response signaling, and sepsis signaling.
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