MAB4147
Anti-MRP1 Antibody, clone MRPm5
clone MRPm5, Chemicon®, from mouse
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
MRPm5, monoclonal
Species reactivity:
human
Application:
FACS, IHC (p), WB
Citations:
9
biological source
mouse
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
MRPm5, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Quality Level
Gene Information
human ... ABCC1(4363)
Immunogen
Bacterial fusion protein of MRP1 containing amino acids 986-1204 of the protein.
Application
Detect MRP1 using this Anti-MRP1 Antibody, clone MRPm5 validated for use in FC, WB, IH, IH(P).
Research Category
Metabolism
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Toxicology & Drug Resistance
Western blotting
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections
Flow Cytometry
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections
Flow Cytometry
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
This antibody reacts with an internal epitope of MRP1, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. The antibody does not cross-react with the human MDR1 and MDR3 gene products.
Physical form
Format: Purified
Purified from tissue culture supernatant, serum-free. Liquid containing 0.7% BSA and 0.1% sodium azide.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer.
Nooter, K, et al.
Annals of Oncology, 7, 75-81 (1996)
Prognostic significance of the immunohistochemical expression of O(6)-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Takao Nakagawa, Kazunori Ido, Takahiro Sakuma, Hiroaki Takeuchi, Kazufumi Sato et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology null
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)
Zhongxing Liang et al.
Pharmaceutical research, 28(12), 3091-3100 (2011-08-20)
To explore whether miR-19 is involved in the regulation of multidrug resistance (MDR), one of the main causes of breast cancer mortality, and modulates sensitivity of tumor cells to chemotherapeutic agents. We analyzed miRNA expression levels in three MDR cell
Zhongxing Liang et al.
Biochemical pharmacology, 79(6), 817-824 (2009-11-04)
Multidrug resistance-associated protein (MRP-1/ABCC1) transports a wide range of therapeutic agents and may play a critical role in the development of multidrug resistance (MDR) in tumor cells. However, the regulation of MRP-1 remains controversial. To explore whether miRNAs are involved
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