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Merck
CN

MAB5790-I

Anti-DSD-1 Antibody, clone 473HD

clone 473HD, from rat

别名:

DSD-1-proteoglycan

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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生物来源

rat

质量水平

100

偶联物

unconjugated

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

473HD, monoclonal

种属反应性

mouse

技术

immunohistochemistry: suitable
western blot: suitable

同位素/亚型

IgMκ

NCBI登记号

NP_001074775

UniProt登记号

Q9WUT8

运输

wet ice

靶向翻译后修饰

unmodified

一般描述

Anti-DSD-1 reacts with a glycosaminoglycan epitope selectively expressed on radial gliacytes of which a subpopulation shows stem cell properties. Cells isolated with this antibody from embryonic mouse tissue had multipotent characteristics and could turn into neurons, astrocytes and oligodendrocytes. The epitope is highly conserved and has been found in several vertebrates.
~400 kDa observed

免疫原

Purified tissue fraction corresponding to mouse DSD-1.

应用

Anti-DSD-1 Antibody, clone 473HD is an antibody against DSD-1, clone 473HD for use in Western Blotting, Immunohistochemistry.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DSD-1 in mouse hippocampus, mouse cerebellum, and mouse embryo tissue.

外形

Format: Purified
Purified rat monoclonal IgMκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

分析说明

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected DSD-1 in 10 µg of mouse brain tissue lysate.

其他说明

Concentration: Please refer to lot specific datasheet.
Replaces: MAB5790

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Zaman Mirzadeh et al.
Nature metabolism, 1(2), 212-221 (2019-06-28)
In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal development of neurocircuits in the hypothalamic arcuate nucleus (ARC)1, a critical brain area for energy and glucose homeostasis2,3. As this developmental defect can be remedied by systemic leptin administration

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