Anti-ADNP1 Antibody, clone 5F5.1

ADNP1, also known as Activity-dependent neuroprotector homeobox protein, and encoded by the gene ADNP/ADNP1/KIAA0784, is a potential transcription factor that appears to mediate some of the neuroprotective peptide VIP associated effects involving normal growth and cancer proliferation. ADNP1 is widely expressed and localized to the nucleus. ADNP1 is strongly expressed in heart and skeletal muscle tissue and the brain. ADNP1 is also found expressed in colon and breast cancer tissues but not in normal tissues, thus ADNP1 can be used as a potential cancer marker in some tissues. ADNP1 is upregulated in normal proliferative tissues by VIP, and it may increase the viability of certain cell types through the modulation of p53 activity. Interestingly, new research shows that ADNP1 may be a potential biomarker for Alzheimer’s disease, where ADP1 expression was specifically down-regulated in AD patients.

Epitope: Near C-terminus

GST-tagged recombinant protein corresponding to human ADNP1, near the C-terminus.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-ADNP1 Antibody, clone 5F5.1 is validated for use in Western Blotting for the detection of ADNP1.

Evaluated by Western Blotting in SH-SY-5Y cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected ADNP1 in 200 µg of SH-SY-5Y cell lysate.

~145 kDa observed

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.