Anti-Prohormone Convertase PC1/PC3 Antibody

Observed at 95 KDa because of multiple glycosylation.

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.

Epitope: Mature Chain

This antibody is generated from rabbits immunized with a KLH conjugated linear peptide within human Prohormone Convertase PC1/PC3.

Anti-Prohormone Convertase PC1/PC3 Antibody is an antibody against Prohormone Convertase PC1/PC3 for use in WB, IC, IH.

Immunocytochemistry Analysis: 1: 500 dilution from a previous lot detected Prohormone Convertase PC1/PC3 in HeLa, C2C12, NIH/3T3 cell lysates.

Research Category
Neuroscience

Research Sub Category
CNS Control of Metabolism

This antibody recognizes Prohormone Convertase PC1/PC3.

Affinity purified

Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.

Maintain refrigerated at 2-8°C for up to 12 months.

Control
Mouse adrenal gland tissue lysate

Evaluated by Western Blot in mouse adrenal gland tissue lysate.
Western Blot Analysis: : 0.5 µg/mL of this lot detected Prohormone Convertase PC1/PC3 on 10 µg of mouse adrenal gland tissue lysate.

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