AB2231
Anti-Dopamine Transporter; 100 µg Antibody
from rabbit
别名:
DA transporter, dopamine transporter, solute carrier family 6 (neurotransmitter transporter, dopamine),member 3, variable number tandem repeat (VNTR)
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
40
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Slc6A3(13162)
rat ... Slc6A3(24898)
General description
Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT), a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson′s disease, Tourette′s disease, schizophrenia, and addiction. DAT is also the target of several “DAT-blockers” including amphetamines and cocaine. These chemicals inhibit the action of DAT and, to a lesser extent, the other monoamine transporters, but their effects are mediated by separate mechanisms.
~ 50 – 80 kDa
Reduced form at approx 50 kDa and Non-reduced form at approx. 80 kDa
Reduced form at approx 50 kDa and Non-reduced form at approx. 80 kDa
Application
This Anti-Dopamine Transporter, 100 µg Antibody is validated for use in WB for the detection of Dopamine Transporter, 100 µg.
Biochem/physiol Actions
Cat. AB2231 recognizes the N-terminus of the reduced and non reduced forms of DAT.
Physical form
Format: Purified
Analysis Note
Routinelyevaluated by western blot on rat brain lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits.
Sauerbeck, A; Hunter, R; Bing, G; Sullivan, PG
Experimental neurology null
Daniel W Curry et al.
Neuropharmacology, 128, 196-206 (2017-10-11)
S,R(+/-)-3,4-methylenedioxymethamphetamine (SR-MDMA) is an amphetamine derivative with prosocial and putative therapeutic effects. Ongoing clinical trials are investigating it as a treatment for post-traumatic stress disorder (PTSD) and other conditions. However, its potential for adverse effects such as hyperthermia and neurotoxicity
Dafina M Angelova et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(2), 995-1006 (2017-10-22)
α-Synuclein (α-syn) is associated with a range of diseases, including Parkinson disease. In disease, α-syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α-syn results in the formation of stellate toxic oligomers
Chunxiao Qi et al.
The Journal of endocrinology, 237(2), 193-205 (2018-03-23)
The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis
Gaia Faustini et al.
Neurobiology of disease, 138, 104789-104789 (2020-02-08)
Loss of dopaminergic nigrostriatal neurons and fibrillary α-synuclein (α-syn) aggregation in Lewy bodies (LB) characterize Parkinson's disease (PD). We recently found that Synapsin III (Syn III), a phosphoprotein regulating dopamine (DA) release with α-syn, is another key component of LB
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