AB2231
Anti-Dopamine Transporter; 100 µg Antibody
from rabbit
别名:
DA transporter, dopamine transporter, solute carrier family 6 (neurotransmitter transporter, dopamine),member 3, variable number tandem repeat (VNTR)
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
mouse, rat
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Slc6A3(13162)
rat ... Slc6A3(24898)
一般描述
Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT), a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson′s disease, Tourette′s disease, schizophrenia, and addiction. DAT is also the target of several “DAT-blockers” including amphetamines and cocaine. These chemicals inhibit the action of DAT and, to a lesser extent, the other monoamine transporters, but their effects are mediated by separate mechanisms.
~ 50 – 80 kDa
Reduced form at approx 50 kDa and Non-reduced form at approx. 80 kDa
Reduced form at approx 50 kDa and Non-reduced form at approx. 80 kDa
应用
This Anti-Dopamine Transporter, 100 µg Antibody is validated for use in WB for the detection of Dopamine Transporter, 100 µg.
生化/生理作用
Cat. AB2231 recognizes the N-terminus of the reduced and non reduced forms of DAT.
外形
Format: Purified
分析说明
Routinelyevaluated by western blot on rat brain lysate.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Daniel W Curry et al.
Neuropharmacology, 128, 196-206 (2017-10-11)
S,R(+/-)-3,4-methylenedioxymethamphetamine (SR-MDMA) is an amphetamine derivative with prosocial and putative therapeutic effects. Ongoing clinical trials are investigating it as a treatment for post-traumatic stress disorder (PTSD) and other conditions. However, its potential for adverse effects such as hyperthermia and neurotoxicity
Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits.
Sauerbeck, A; Hunter, R; Bing, G; Sullivan, PG
Experimental neurology null
Chunxiao Qi et al.
The Journal of endocrinology, 237(2), 193-205 (2018-03-23)
The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis
Marion France et al.
Experimental physiology, 101(1), 81-99 (2015-09-19)
Obesity alters gastrointestinal (GI) motility and 5-HT signalling. Altered 5-HT signalling disrupts control of GI motility. Levels of extracellular 5-HT depend on enterochromaffin (EC) cell release and serotonin transporter (SERT) uptake. We assessed GI transit and 5-HT signalling in the
Jackson J Cone et al.
PloS one, 8(3), e58251-e58251 (2013-03-22)
The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine signaling, including dopamine transporter (DAT) expression and dopamine reuptake. However, the time-course of diet-induced changes in DAT expression and function and whether such changes are dependent upon
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