AB3000
抗IP3受体II型抗体
Chemicon®, from rabbit
别名:
Inositol 1,4,5-Trisphosphate Receptor
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IF, IHC, IP, WB
Citations:
17
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, hamster, human, monkey, rat
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITPR2(3709)
Immunogen
一种对应于大鼠II型受体羧基末端的合成肽
Application
抗IP3受体II型抗体检测IP3受体II型的水平 &经发布 & 经验证可用于IC、IF、IH、IP & WB。
研究子类别
GPCR, cAMP/cGMP & 钙信号传导
GPCR, cAMP/cGMP & 钙信号传导
研究类别
信号传导
信号传导
蛋白质印迹：1:50 - 1:100（检测260 kDa条带）
免疫荧光： 1:10 - 1:20
免疫沉淀
免疫细胞化学：已知对AR4-2J，HL-60，COS-1，HEK-293和RBL-2H3细胞系具有阳性反应性。
免疫组化：多聚甲醛或甲醇固定剂有效。
最佳工作稀释度必须由最终用户进行确定。
免疫荧光： 1:10 - 1:20
免疫沉淀
免疫细胞化学：已知对AR4-2J，HL-60，COS-1，HEK-293和RBL-2H3细胞系具有阳性反应性。
免疫组化：多聚甲醛或甲醇固定剂有效。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
兔抗II型肌醇1，4，5-三磷酸受体（IP3R）针对对应于大鼠II型受体羧基末端的合成肽。 该抗体可与来自大鼠、小鼠、人、仓鼠和猴的II型IP3R反应。
Physical form
亲和纯化与固定化免疫原肽。 PBS缓冲液中的液体，含有0.05%BSA，10%甘油，0.005%叠氮化钠。 注意：叠氮化钠是有害的。 可根据要求提供MSDS。
Preparation Note
若是保持冷冻在 -20°C 下，未稀释等分试样可保存长达 12 个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Still not finding the right product?
试用我们的 产品选型工具 工具缩小选择范围
存储类别
10 - Combustible liquids
wgk
WGK 2
Robert P Brumer et al.
The Journal of physiology, 601(8), 1383-1405 (2023-03-04)
Excess consumption of carbohydrates, fat and calories leads to non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance; these are major factors in the pathogenesis of type II diabetes. Hormones and catecholamines acting through G-protein coupled receptors (GPCRs) linked to
Mark Chalmers et al.
The Biochemical journal, 394(Pt 1), 57-66 (2005-11-09)
The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not
Shafi Kuchay et al.
Nature, 546(7659), 554-558 (2017-06-15)
In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2+