产品名称
抗IP3受体II型抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, hamster, human, monkey, rat
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITPR2(3709)
Application
抗IP3受体II型抗体检测IP3受体II型的水平 &经发布 & 经验证可用于IC、IF、IH、IP & WB。
研究子类别
GPCR, cAMP/cGMP & 钙信号传导
GPCR, cAMP/cGMP & 钙信号传导
研究类别
信号传导
信号传导
蛋白质印迹：1:50 - 1:100（检测260 kDa条带）
免疫荧光： 1:10 - 1:20
免疫沉淀
免疫细胞化学：已知对AR4-2J，HL-60，COS-1，HEK-293和RBL-2H3细胞系具有阳性反应性。
免疫组化：多聚甲醛或甲醇固定剂有效。
最佳工作稀释度必须由最终用户进行确定。
免疫荧光： 1:10 - 1:20
免疫沉淀
免疫细胞化学：已知对AR4-2J，HL-60，COS-1，HEK-293和RBL-2H3细胞系具有阳性反应性。
免疫组化：多聚甲醛或甲醇固定剂有效。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
兔抗II型肌醇1，4，5-三磷酸受体（IP3R）针对对应于大鼠II型受体羧基末端的合成肽。 该抗体可与来自大鼠、小鼠、人、仓鼠和猴的II型IP3R反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
一种对应于大鼠II型受体羧基末端的合成肽
Physical form
亲和纯化与固定化免疫原肽。 PBS缓冲液中的液体，含有0.05%BSA，10%甘油，0.005%叠氮化钠。 注意：叠氮化钠是有害的。 可根据要求提供MSDS。
Preparation Note
若是保持冷冻在 -20°C 下，未稀释等分试样可保存长达 12 个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
Shafi Kuchay et al.
Nature, 546(7659), 554-558 (2017-06-15)
In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2+
Mark Chalmers et al.
The Biochemical journal, 394(Pt 1), 57-66 (2005-11-09)
The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not
Robert P Brumer et al.
The Journal of physiology, 601(8), 1383-1405 (2023-03-04)
Excess consumption of carbohydrates, fat and calories leads to non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance; these are major factors in the pathogenesis of type II diabetes. Hormones and catecholamines acting through G-protein coupled receptors (GPCRs) linked to
Ji-Wei Li et al.
Oncotarget, 7(40), 65849-65861 (2016-09-03)
Oxsterol binding protein-related protein 4 (ORP4) is essential for cell proliferation, but the underlying mechanism is unclear. ORP4 is expressed as three variants, ORP4L, ORP4M and ORP4S. Here, we reported that silencing of ORP4L with specific small interfering RNA (siRNA)
Takahiro Fujimoto et al.
International journal of molecular medicine, 30(6), 1287-1293 (2012-09-21)
KRAS-induced actin-interacting protein (KRAP), originally identified as one of the deregulated genes expressed in colorectal cancer, participates under physiological conditions in the regulation of systemic energy homeostasis and of the exocrine system. We have recently found that KRAP is a
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