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Merck
CN

AB3562P

抗-Na+/K+/Cl-共转运蛋白2抗体

Chemicon®, from rabbit

别名:

NKCC2

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
Species reactivity:
mouse, rat
Citations:
21
Technique(s):
ELISA: suitable
western blot: suitable
Uniprot accession no.:
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产品名称

抗-Na+/K+/Cl-共转运蛋白2抗体, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... SLC12A1(6557)

Application

抗-Na+/K+/Cl-共转运蛋白2抗体可检测Na+/K+/Cl-共转运蛋白2的水平&已有相关文献发表&经验证可用于ELISA& WB。
研究子类别
离子通道 & 转运蛋白
研究类别
神经科学
蛋白质印迹:使用ECL为1-10μg/mL全长人NKCC2为~150 kDa。



ELISA:0.5-1 μg/mL,使用每孔1 μg/mL对照肽。

最佳工作稀释度必须由最终用户进行确定。

Biochem/physiol Actions

可识别大鼠钠钾氯共转运蛋白2(NKCC2、BSC1、CCC2)。免疫原与NKCC1或TSC没有明显的序列同源性。

物种反应性: 免疫原序列在小鼠中100%保守,在人和兔中87%保守。与其他物种的反应性尚未得到确认。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

大鼠NKCC2 C末端附近的15个氨基酸肽序列(Haas et al. 1987; Gamba et al. 1994; Simon et al. 1996; Mount et al. 1995; Igarashi et al. 1995; Mount et al. 1998)。免疫原肽(AG205)可用于进行预吸收对照。

Other Notes

浓度:请参考批次特异性浓缩物的检验报告。

Physical form

亲和纯化的免疫球蛋白。 含0.1%BSA的PBS液体。

Preparation Note

以未稀释的等分试样保存于-20°C下6个月。应避免反复冻/融循环。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Matteo Trudu et al.
Nature medicine, 19(12), 1655-1660 (2013-11-05)
Hypertension and chronic kidney disease (CKD) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter of the UMOD gene, which encodes uromodulin, the major protein secreted in normal urine, that
Determination of uromodulin in human urine: influence of storage and processing.
Youhanna, S; Weber, J; Beaujean, V; Glaudemans, B; Sobek, J; Devuyst, O
Nephrology, Dialysis, and Transplantation null
Serena Milano et al.
Journal of cellular and molecular medicine, 28(8), e18301-e18301 (2024-04-23)
X-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure
Agnieszka Konopacka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5144-5155 (2015-04-04)
The Na-K-2Cl cotransporter 2 (NKCC2) was thought to be kidney specific. Here we show expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress. The HNS controls osmotic stability through the synthesis and release of the neuropeptide hormone
Giuseppe Procino et al.
Kidney international, 90(3), 555-567 (2016-05-22)
To date, the study of the sympathetic regulation of renal function has been restricted to the important contribution of β1- and β2-adrenergic receptors (ARs). Here we investigate the expression and the possible physiologic role of β3-adrenergic receptor (β3-AR) in mouse

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