AB3562P
抗-Na+/K+/Cl-共转运蛋白2抗体
Chemicon®, from rabbit
别名:
NKCC2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
mouse, rat
Citations:
21
Technique(s):
ELISA: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-Na+/K+/Cl-共转运蛋白2抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC12A1(6557)
Application
抗-Na+/K+/Cl-共转运蛋白2抗体可检测Na+/K+/Cl-共转运蛋白2的水平&已有相关文献发表&经验证可用于ELISA& WB。
研究子类别
离子通道 & 转运蛋白
离子通道 & 转运蛋白
研究类别
神经科学
神经科学
蛋白质印迹：使用ECL为1-10μg/mL全长人NKCC2为~150 kDa。
ELISA：0.5-1 μg/mL，使用每孔1 μg/mL对照肽。
最佳工作稀释度必须由最终用户进行确定。
ELISA：0.5-1 μg/mL，使用每孔1 μg/mL对照肽。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
可识别大鼠钠钾氯共转运蛋白2（NKCC2、BSC1、CCC2）。免疫原与NKCC1或TSC没有明显的序列同源性。
物种反应性： 免疫原序列在小鼠中100%保守，在人和兔中87%保守。与其他物种的反应性尚未得到确认。
物种反应性： 免疫原序列在小鼠中100%保守，在人和兔中87%保守。与其他物种的反应性尚未得到确认。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
大鼠NKCC2 C末端附近的15个氨基酸肽序列（Haas et al. 1987; Gamba et al. 1994; Simon et al. 1996; Mount et al. 1995; Igarashi et al. 1995; Mount et al. 1998）。免疫原肽（AG205）可用于进行预吸收对照。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化的免疫球蛋白。 含0.1%BSA的PBS液体。
Preparation Note
以未稀释的等分试样保存于-20°C下6个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Matteo Trudu et al.
Nature medicine, 19(12), 1655-1660 (2013-11-05)
Hypertension and chronic kidney disease (CKD) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter of the UMOD gene, which encodes uromodulin, the major protein secreted in normal urine, that
Determination of uromodulin in human urine: influence of storage and processing.
Youhanna, S; Weber, J; Beaujean, V; Glaudemans, B; Sobek, J; Devuyst, O
Nephrology, Dialysis, and Transplantation null
Serena Milano et al.
Journal of cellular and molecular medicine, 28(8), e18301-e18301 (2024-04-23)
X-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure
Agnieszka Konopacka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5144-5155 (2015-04-04)
The Na-K-2Cl cotransporter 2 (NKCC2) was thought to be kidney specific. Here we show expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress. The HNS controls osmotic stability through the synthesis and release of the neuropeptide hormone
Giuseppe Procino et al.
Kidney international, 90(3), 555-567 (2016-05-22)
To date, the study of the sympathetic regulation of renal function has been restricted to the important contribution of β1- and β2-adrenergic receptors (ARs). Here we investigate the expression and the possible physiologic role of β3-adrenergic receptor (β3-AR) in mouse
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