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Merck
CN

AB3562P

抗-Na+/K+/Cl-共转运蛋白2抗体

Chemicon®, from rabbit

别名:

NKCC2

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
Species reactivity:
mouse, rat
Citations:
21
Technique(s):
ELISA: suitable
western blot: suitable
Uniprot accession no.:
Q13621

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产品名称

抗-Na+/K+/Cl-共转运蛋白2抗体, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_000338.2

UniProt accession no.

Q13621

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SLC12A1(6557)

Application

抗-Na+/K+/Cl-共转运蛋白2抗体可检测Na+/K+/Cl-共转运蛋白2的水平&已有相关文献发表&经验证可用于ELISA& WB。
研究子类别
离子通道 & 转运蛋白
研究类别
神经科学
蛋白质印迹：使用ECL为1-10μg/mL全长人NKCC2为~150 kDa。



ELISA：0.5-1 μg/mL，使用每孔1 μg/mL对照肽。

最佳工作稀释度必须由最终用户进行确定。

Biochem/physiol Actions

可识别大鼠钠钾氯共转运蛋白2（NKCC2、BSC1、CCC2）。免疫原与NKCC1或TSC没有明显的序列同源性。

物种反应性： 免疫原序列在小鼠中100%保守，在人和兔中87%保守。与其他物种的反应性尚未得到确认。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

大鼠NKCC2 C末端附近的15个氨基酸肽序列（Haas et al. 1987; Gamba et al. 1994; Simon et al. 1996; Mount et al. 1995; Igarashi et al. 1995; Mount et al. 1998）。免疫原肽（AG205）可用于进行预吸收对照。

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Physical form

亲和纯化的免疫球蛋白。 含0.1%BSA的PBS液体。

Preparation Note

以未稀释的等分试样保存于-20°C下6个月。应避免反复冻/融循环。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Serena Milano et al.
Journal of cellular and molecular medicine, 28(8), e18301-e18301 (2024-04-23)
X-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure
Agnieszka Konopacka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5144-5155 (2015-04-04)
The Na-K-2Cl cotransporter 2 (NKCC2) was thought to be kidney specific. Here we show expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress. The HNS controls osmotic stability through the synthesis and release of the neuropeptide hormone
Determination of uromodulin in human urine: influence of storage and processing.
Youhanna, S; Weber, J; Beaujean, V; Glaudemans, B; Sobek, J; Devuyst, O
Nephrology, Dialysis, and Transplantation null
Giuseppe Procino et al.
Kidney international, 90(3), 555-567 (2016-05-22)
To date, the study of the sympathetic regulation of renal function has been restricted to the important contribution of β1- and β2-adrenergic receptors (ARs). Here we investigate the expression and the possible physiologic role of β3-adrenergic receptor (β3-AR) in mouse
Matteo Trudu et al.
Nature medicine, 19(12), 1655-1660 (2013-11-05)
Hypertension and chronic kidney disease (CKD) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter of the UMOD gene, which encodes uromodulin, the major protein secreted in normal urine, that
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