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Merck
CN

AB5675

抗代谢型谷氨酸受体5抗体，疼痛

Chemicon®, from rabbit

别名:

Metabotropic glutamate receptor 5, Metabotropic Glutamate Receptor 5 Antibody, mGluR5, Anti-mGluR5

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗代谢型谷氨酸受体5抗体，疼痛, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse

species reactivity (predicted by homology)

human (based on 100% sequence homology), bovine (based on 100% sequence homology), primate (based on 100% sequence homology), horse (based on 100% sequence homology), feline (based on 100% sequence homology)

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001137306

UniProt accession no.

Q3UVX5

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GRM5(2915)

相关类别

Analysis Note

对照
脑组织
通过蛋白质印迹对大鼠脑组织裂解物的微粒体制剂进行了评估。

蛋白质印迹分析：2.0 µg/mL 的该抗体在 10 µg大鼠脑组织裂解物的微粒体制剂中检测到代谢型谷氨酸受体5。

Application

抗代谢型谷氨酸受体5抗体，疼痛是用于IH &WB的一种针对代谢型谷氨酸受体5的抗体。
研究子类别
神经递质& 受体
研究类别
神经科学
蛋白印迹分析: 0.1-0.5 μg/mL，大鼠脑微粒体制备使用ECL。与~132 kDa的条带反应。
免疫组化：在用含15%饱和苦味酸的4%多聚甲醛的0.1 M PB、pH值7.4固定的大鼠脑和小鼠脑切片上为0.1-0.2 μg/ml。
免疫组化分析：代表性批次的1：50稀释液在小鼠后脑和大鼠结肠组织中检测到代谢型谷氨酸受体5。

Biochem/physiol Actions

该抗体不能检测亚型2。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

代谢型谷氨酸受体5或mGluR5（UniProt Q3UVX5；也称为G蛋白偶联受体GRM5，G蛋白偶联受体家族C，第1组，成员E）由鼠种中的Grm5（也称为Gprc1e，Mglur5，AI850523、6430542K11Rik）基因编码（基因ID 108071）。代谢型谷氨酸受体属于G蛋白偶联受体家族，根据其序列同源性，推定的信号转导机制和药理特性将其分为3类。mGluR1和mGluR5构成I类代谢型谷氨酸受体。在神经元和小胶质细胞的突触后末端发现了mGluR5。mGluR5通过Gq/G11偶联发出信号以激活磷脂酶C，从而导致钙动员和蛋白激酶C（PKC）激活。此外，据报告，mGluR5还以不依赖G蛋白的方式介导涉及Src家族蛋白酪氨酸激酶的信号传导。
观察值〜150 kDa。某些裂解液可能会出现未表征的条带。

Immunogen

KLH偶联的线性肽，对应于大鼠代谢型谷氨酸受体5的细胞质域。

Other Notes

2024年CiteAb奖，授予在帕金森研究方面取得成功的供应商
替代品：AB1596；06-451

Physical form

免疫亲和纯化
纯化的兔多克隆抗体，溶于含0.05％叠氮化钠的PBS缓冲液中

Preparation Note

自收到之日起，在 2-8°C 条件下可稳定保存1年

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Pratyush S Suryavanshi et al.
Molecular pharmacology, 90(2), 96-105 (2016-05-28)
The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit
Anthony D Umpierre et al.
Experimental neurology, 279, 116-126 (2016-02-21)
More efficient or translationally relevant approaches are needed to model acquired temporal lobe epilepsy (TLE) in genetically tractable mice. The high costs associated with breeding and maintaining transgenic, knock-in, or knock-out lines place a high value on the efficiency of
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