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Merck
CN

AB9234

Anti-Beta (β)-Amyloid antibody

CHEMICON®, rabbit polyclonal

别名:

Anti-oligomer

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关于此项目

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
rat, eukaryotes, mouse
Application:
ELISA, IF, IHC (p), IP, WB
Citations:
48
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产品名称

抗淀粉样蛋白寡聚体抗体,αβ,寡聚体, serum, Chemicon®

biological source

rabbit

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, eukaryotes, mouse

species reactivity (predicted by homology)

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable, immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... APP(351)

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General description

淀粉样蛋白单体蛋白有时可以寡聚化为破坏性淀粉样蛋白原纤维。 非疾病相关蛋白的淀粉样构象可以通过部分蛋白错误折叠或变性产生。 在疾病状态的寡聚化中,广泛的淀粉样蛋白寡聚化会在与阿尔茨海默’病相关的神经组织中形成斑块。

Immunogen

表位:寡聚

Application

免疫组化:
先前批次使用1:1,000-1:10,000的浓度。

免疫沉淀:
先前批次使用了1:1,000的浓度。建议的细胞裂解缓冲液为RIPA。建议的捕获剂是磁珠(Dynabeads)。已知共沉淀多肽:淀粉样蛋白β,α突触核蛋白寡聚体。

ELISA(直接):
先前批次的该抗体已用于ELISA。

最佳工作稀释度必须由最终用户确定。
抗淀粉样蛋白寡聚体抗体,αβ,寡聚是一种抗淀粉样蛋白寡聚体的抗体,用于ELISA、IF、IH、IH(P)、IP &WB。
研究子类别
神经退行性疾病
研究类别
神经科学

Biochem/physiol Actions

可识别淀粉样蛋白寡聚体。该抗体识别全部类型的淀粉样蛋白寡聚体。该抗体似乎可识别肽骨架表位,其在淀粉样蛋白寡聚体常见,但在天然蛋白,淀粉样单体或成熟淀粉样蛋白原纤维中未发现。该抗体被称为A11。

Physical form

兔血清。不含防腐剂。
未纯化

Preparation Note

自收到之日起在-20ºC可稳定保存1年。

Analysis Note

对照
已通过蛋白质印迹对小鼠脑裂解物进行了评估。

蛋白质印迹分析:
该抗体的1:500的稀释液在10 μg小鼠脑裂解物中检测到淀粉样蛋白寡聚体。

Other Notes

浓度:请参考批次特异性浓缩物的分析证书。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

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Sónia S Leal et al.
The Journal of biological chemistry, 288(35), 25219-25228 (2013-07-19)
Imbalance in metal ion homeostasis is a hallmark in neurodegenerative conditions involving protein deposition, and amyotrophic lateral sclerosis (ALS) is no exception. In particular, Ca(2+) dysregulation has been shown to correlate with superoxide dismutase-1 (SOD1) aggregation in a cellular model
Carolyn Hollands et al.
Molecular neurodegeneration, 12(1), 64-64 (2017-09-10)
The molecular mechanism underlying progressive memory loss in Alzheimer's disease is poorly understood. Neurogenesis in the adult hippocampus is a dynamic process that continuously changes the dentate gyrus and is important for hippocampal plasticity, learning and memory. However, whether impairments
Gabriel Fung et al.
Oncotarget, 8(43), 74767-74780 (2017-11-02)
Protein quality control (PQC) plays a key role in maintaining cardiomyocyte function and homeostasis, and malfunction in PQC is implicated in various forms of heart diseases. Molecular chaperones serve as the primary checkpoint for PQC; however, their roles in the
Hugo M Botelho et al.
The Journal of biological chemistry, 287(50), 42233-42242 (2012-10-19)
S100A6 is a small EF-hand calcium- and zinc-binding protein involved in the regulation of cell proliferation and cytoskeletal dynamics. It is overexpressed in neurodegenerative disorders and a proposed marker for Amyotrophic Lateral Sclerosis (ALS). Following recent reports of amyloid formation
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
Kim, HJ; Chang, KA; Ha, TY; Kim, J; Ha, S; Shin, KY; Moon, C; Nacken, W; Kim, HS; Suh, YH
Testing null

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