ABN410
抗-ZNF423抗体
from rabbit, purified by affinity chromatography
别名:
Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein, ZFP423
登录 查看组织和合同定价。
选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rat, human, mouse
Citations:
5
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Uniprot accession no.:
产品名称
抗-ZNF423抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human, mouse
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ZNF423(23090)
Analysis Note
通过蛋白质印迹在小鼠P7脑组织裂解液中进行了评估。
蛋白质印迹分析：2 µg/mL的该抗体可在10 µg小鼠P7脑组织裂解液中检测到ZNF423。
蛋白质印迹分析：2 µg/mL的该抗体可在10 µg小鼠P7脑组织裂解液中检测到ZNF423。
Application
免疫组化分析：代表性批次的1：500和1：50稀释液分别在人和大鼠小脑组织中检测到ZNF423。
免疫组化分析：代表性批次的1：500稀释液在人类丘脑和海马组织中检测到ZNF423。
免疫细胞化学分析：代表性批次的1：100稀释液在NIH/3T3细胞中检测到ZNF423。
DyLight®是Thermo Fisher Scientific的注册商标。
免疫组化分析：代表性批次的1：500稀释液在人类丘脑和海马组织中检测到ZNF423。
免疫细胞化学分析：代表性批次的1：100稀释液在NIH/3T3细胞中检测到ZNF423。
DyLight®是Thermo Fisher Scientific的注册商标。
抗ZNF423抗体是一种针对ZNF423的抗体，用于免疫印迹，IHC（石蜡）&ICC。
研究子类别
发育神经科学
发育神经科学
研究类别
神经科学
神经科学
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
ZNF423，也称为锌指蛋白423，Olf1/EBF相关的锌指蛋白，hOAZ或Smad和Olf相互作用的锌指蛋白，由基因ZNF423/KIAA0760/NPHP14/OAZ编码，是一种转录因子，可以根据环境同时充当激活剂或阻遏物。ZNF423在BMP信号传导和嗅觉神经发生中起着核心作用。ZNF423通过与EBF1的相互作用而充当转录阻遏物，EBF1是参与末端嗅觉受体神经元分化的转录因子。ZNF423通过参与调节嗅觉受体神经元从分化到成熟的过渡的发育转换而参与嗅觉神经发生，并且它控制小脑蚓部形成中神经前体的增殖和分化。在胎儿和成人状态下，ZNF423在许多器官中表达，包括脑，肺，骨骼肌和心脏。ZNF423的缺陷会导致遗传性肾脏疾病肾消耗病和称为先天性小脑蚓部发育不全的神经障碍。
观察值〜125 kDa。在某些细胞裂解物中可能会观察到未表征的条带。
Immunogen
KLH-偶联的线性肽，对应于人ZNF423的C末端附近的区域。（注意：免疫原与牛有93%的序列同源性。）
表位：近C端
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
Legal Information
DyLight is a registered trademark of Pierce Biotechnology, Inc.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Gen Wang et al.
Breast cancer research and treatment, 175(3), 567-578 (2019-04-03)
In early stage, ERα-positive breast cancer, concurrent use of endocrine therapy and chemotherapy has not been shown to be superior to sequential use. We hypothesized that genetic biomarkers can aid in selecting patients who would benefit from chemo-endocrine therapy. Our
Thanh N Dang et al.
BMC cancer, 22(1), 300-300 (2022-03-23)
Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared
William N Addison et al.
Molecular and cellular biology, 39(8) (2019-01-30)
Satellite cells (SCs) are skeletal muscle stem cells that proliferate in response to injury and provide myogenic precursors for growth and repair. Zfp423 is a transcriptional cofactor expressed in multiple immature cell populations, such as neuronal precursors, mesenchymal stem cells
Ojas Deshpande et al.
PLoS genetics, 16(9), e1009017-e1009017 (2020-09-15)
Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects several developmental pathways. ZNF423 has been implicated in rare
Chen-Cheng Lee et al.
Molecular cell, 76(3), 500-515 (2019-08-20)
Diet-induced obesity can be caused by impaired thermogenesis of beige adipocytes, the brown-like adipocytes in white adipose tissue (WAT). Promoting brown-like features in WAT has been an attractive therapeutic approach for obesity. However, the mechanism underlying beige adipocyte formation is
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持