Anti-Capicua Antibody

Protein capicua homolog (CIC) , also known as Capicua Transcriptional Repressor, Capicua Homolog, and encoded by the gene CIC, is a transcriptional repressor which plays a role in development of the central nervous system (CNS). CIC is a new subfamily of the HMG-box superfamily and the gene′s expression is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS, and thus the gene is implicated in CNS development, in particular in granule cell development. CIC appears to be central to cerebellar development and ErbB signaling as well. Recent research has demonstrated that CIC is highly expressed in certain cancers including medulloblastomas, but also the loss of expression may serve as a biomarker for other cancer types such as oligodendrogliomas.

~160 kDa observed. Long isoform can be detected at ~250kDa with longer exposure, in some lysates (Kim, E., et al. (2013). Genea Dev. 27:590-595).

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human Capicua near the N-terminal.

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Capicua in human cerebral cortex tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Capicua Antibody is validated for use in Western Blotting for the detection of Capicua.

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in human cerebellum tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Capicua in 10 µg of human cerebellum tissue lysate.

Concentration: Please refer to lot specific datasheet.

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