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Merck
CN

MAB1281

抗核抗体，克隆235-1

clone 235-1, Chemicon®, from mouse

别名:

HuNu

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗核抗体，克隆235-1, clone 235-1, Chemicon®, from mouse

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

235-1, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable

input

sample type neural stem cell(s)

isotype

IgG1

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

相关类别

Analysis Note

对照
所有人类细胞类型

Application

抗核抗体，克隆235-1已用于：免疫组织化学(1:200)；人细胞核免疫标记(HuNu) (1:300)；颌下腺的组织学和免疫荧光分析

Biochem/physiol Actions

人核单克隆抗体与人细胞特异性反应。 在免疫组化中，它对小鼠、大鼠、鸡没有反应性。 尚未测试其他哺乳动物或动物物种的反应性。
染色所有人类细胞类型的细胞核，使细胞核呈弥漫性染色。 中期细胞的染色体染色呈阴性。还可以染色灵长类动物的细胞核（Sanchez-Pernaute, 2005）。抗体不与小鼠或大鼠的细胞核反应。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

干细胞或胚胎细胞疗法等细胞替代技术对许多疾病具有巨大的应用潜力。 人与动物细胞或组织之间的跨物种移植需要在宿主环境中鉴定和定位供体材料。抗核抗体是有用的细胞学和组织学标志物，可用于鉴定异种移植模型中的人类细胞。

Other Notes

2024年CiteAb奖，授予在帕金森研究方面取得成功的供应商

Physical form

形式：纯化
杂交瘤上清液。溶于PBS中的液体。不含防腐剂。
纯化的蛋白 A

Preparation Note

自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始样品瓶进行离心。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Human stem cell delivery for treatment of large segmental bone defects.
Dupont, KM; Sharma, K; Stevens, HY; Boerckel, JD; Garcia, AJ; Guldberg, RE
Proceedings of the National Academy of Sciences of the USA null
Jun Lei et al.
American journal of obstetrics and gynecology, 212(5), 639-639 (2015-01-04)
Using a mouse model of intrauterine inflammation, we have demonstrated that exposure to inflammation induces preterm birth and perinatal brain injury. Mesenchymal stem cells (MSCs) have been shown to exhibit immunomodulatory effects in many inflammatory conditions. We hypothesized that treatment
Yuelin Zhang et al.
Cell transplantation, 21(10), 2225-2239 (2012-07-11)
Although transplantation of adult bone marrow mesenchymal stem cells (BM-MSCs) holds promise in the treatment for pulmonary arterial hypertension (PAH), the poor survival and differentiation potential of adult BM-MSCs have limited their therapeutic efficiency. Here, we compared the therapeutic efficacy
E Josue Ruiz et al.
Nature communications, 5, 3175-3175 (2014-01-17)
The signals that regulate stem cell self-renewal and differentiation in the lung remain elusive. Lung stem cells undergo self-renewal or lineage commitment to replenish tissue, depending on cross-talk with their environment. This environment, also known as the niche, includes mesenchymal
E E Garanina et al.
Spinal cord, 54(6), 423-430 (2015-10-07)
Experimental study. Several neuro-degenerative disorders such as Alzheimer's dementia, Parkinson's disease and amyotrophic lateral sclerosis (ALS) are associated with genetic mutations, and replacing or disrupting defective sequences might offer therapeutic benefits. Single gene delivery has so far failed to achieve
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